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Sequence Determinants of TDP-43 Ribonucleoprotein Condensate Formation and Axonal Transport in Neurons

Mutations in TDP-43, a RNA-binding protein with multiple functions in RNA metabolism, cause amyotrophic lateral sclerosis (ALS), but it is uncertain how defects in RNA biology trigger motor neuron degeneration. TDP-43 is a major constituent of ribonucleoprotein (RNP) granules, phase separated biomol...

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Detalles Bibliográficos
Autores principales:	Vishal, Sonali S., Wijegunawardana, Denethi, Salaikumaran, Muthu Raj, Gopal, Pallavi P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133736/ https://www.ncbi.nlm.nih.gov/pubmed/35646935 http://dx.doi.org/10.3389/fcell.2022.876893

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