A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges

Chronic myeloid leukemia(CML) is characterized by Philadelphia(Ph) chromosome. About 5% of cases are diagnosed in blast phase. We report a case of a 53-year-old female with no significant medical history, in B-lymphoblast crisis. Flow cytometry demonstrated B-lymphoblasts with no myeloid aberrancies...

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Autores principales: Naiyer, Nada, Zaslav, Ann-Leslie, Ahmed, Tahmeena, Spitzer, Silvia, Ma, Yupo, Ponce, Roxanna, Lee, Htien, Lin, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133756/
https://www.ncbi.nlm.nih.gov/pubmed/35634195
http://dx.doi.org/10.1016/j.lrr.2022.100327
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author Naiyer, Nada
Zaslav, Ann-Leslie
Ahmed, Tahmeena
Spitzer, Silvia
Ma, Yupo
Ponce, Roxanna
Lee, Htien
Lin, Hong
author_facet Naiyer, Nada
Zaslav, Ann-Leslie
Ahmed, Tahmeena
Spitzer, Silvia
Ma, Yupo
Ponce, Roxanna
Lee, Htien
Lin, Hong
author_sort Naiyer, Nada
collection PubMed
description Chronic myeloid leukemia(CML) is characterized by Philadelphia(Ph) chromosome. About 5% of cases are diagnosed in blast phase. We report a case of a 53-year-old female with no significant medical history, in B-lymphoblast crisis. Flow cytometry demonstrated B-lymphoblasts with no myeloid aberrancies, together with immature neutrophils in blood, and B-lymphoblasts in bone marrow. Cytogenetic studies identified Ph+ with complex abnormalities. Molecular analysis showed positive both for p210 and p190 transcripts in blood. ABL1 mutation analysis by Next Generation Sequencing(NGS) detected Thr315Ile mutation, which confers resistance to many tyrosine kinase inhibitors(TKIs). Eight months later she received allogeneic transplant and is doing well.
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spelling pubmed-91337562022-05-27 A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges Naiyer, Nada Zaslav, Ann-Leslie Ahmed, Tahmeena Spitzer, Silvia Ma, Yupo Ponce, Roxanna Lee, Htien Lin, Hong Leuk Res Rep Article Chronic myeloid leukemia(CML) is characterized by Philadelphia(Ph) chromosome. About 5% of cases are diagnosed in blast phase. We report a case of a 53-year-old female with no significant medical history, in B-lymphoblast crisis. Flow cytometry demonstrated B-lymphoblasts with no myeloid aberrancies, together with immature neutrophils in blood, and B-lymphoblasts in bone marrow. Cytogenetic studies identified Ph+ with complex abnormalities. Molecular analysis showed positive both for p210 and p190 transcripts in blood. ABL1 mutation analysis by Next Generation Sequencing(NGS) detected Thr315Ile mutation, which confers resistance to many tyrosine kinase inhibitors(TKIs). Eight months later she received allogeneic transplant and is doing well. Elsevier 2022-05-20 /pmc/articles/PMC9133756/ /pubmed/35634195 http://dx.doi.org/10.1016/j.lrr.2022.100327 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Naiyer, Nada
Zaslav, Ann-Leslie
Ahmed, Tahmeena
Spitzer, Silvia
Ma, Yupo
Ponce, Roxanna
Lee, Htien
Lin, Hong
A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges
title A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges
title_full A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges
title_fullStr A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges
title_full_unstemmed A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges
title_short A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges
title_sort rare case of b-lymphoid blast phase of chronic myeloid leukemia: diagnostic challenges
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133756/
https://www.ncbi.nlm.nih.gov/pubmed/35634195
http://dx.doi.org/10.1016/j.lrr.2022.100327
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