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Attainment of Lipid Targets Following Coronary Artery Bypass Graft Surgery: Can We Do Better?
OBJECTIVE: Patients undergoing coronary artery bypass graft (CABG) surgery remain at high cardiovascular risk; however, few studies have evaluated lipid management and attainment of lipid targets in these patients. We investigated the proportion of CABG surgery patients who attained low-density lipo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Lipidology and Atherosclerosis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133779/ https://www.ncbi.nlm.nih.gov/pubmed/35656149 http://dx.doi.org/10.12997/jla.2022.11.2.187 |
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author | Lan, Nick S. R. Ali, Umar S. Yeap, Bu B. Fegan, P. Gerry Larbalestier, Robert Bell, Damon A. |
author_facet | Lan, Nick S. R. Ali, Umar S. Yeap, Bu B. Fegan, P. Gerry Larbalestier, Robert Bell, Damon A. |
author_sort | Lan, Nick S. R. |
collection | PubMed |
description | OBJECTIVE: Patients undergoing coronary artery bypass graft (CABG) surgery remain at high cardiovascular risk; however, few studies have evaluated lipid management and attainment of lipid targets in these patients. We investigated the proportion of CABG surgery patients who attained low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (HDL-C) targets. METHODS: Data were retrospectively obtained from patients undergoing CABG surgery at an Australian tertiary hospital between February 2015 and August 2020. The most recent lipid profile was recorded (at least 3 weeks post-operatively). We studied patients with electronically available data to ensure accuracy. Target LDL-C was defined as <1.4 (54 mg/dL) and <1.8 mmol/L (70 mg/dL), and target non-HDL-C as <2.2 (85 mg/dL) and <2.6 mmol/L (100 mg/dL), as per the 2019 and 2016 European dyslipidaemia guidelines, respectively. RESULTS: Follow-up lipid results were available for 484 patients (median post-operative follow-up, 483 days; interquartile range, 177.5–938.75 days). The mean age was 62.7±10.5 years and 387 (80.1%) were male. At discharge, 469 (96.9%) patients were prescribed statins, 425 (90.6%) high-intensity. Ezetimibe was prescribed for 62 (12.8%) patients and a proprotein convertase subtilisin-kexin type 9 inhibitor for 1. LDL-C levels <1.4 and <1.8 mmol/L were attained in 118 (24.4%) and 231 (47.7%) patients, respectively, and non-HDL-C levels <2.2 and <2.6 mmol/L in 140 (28.9%) and 237 (49.0%) patients, respectively. CONCLUSION: The use of non-statin lipid-lowering therapies was limited, and many CABG surgery patients did not attain lipid targets despite high-intensity statins. Further studies are required to optimise lipid management in this very high-risk population. |
format | Online Article Text |
id | pubmed-9133779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society of Lipidology and Atherosclerosis |
record_format | MEDLINE/PubMed |
spelling | pubmed-91337792022-06-01 Attainment of Lipid Targets Following Coronary Artery Bypass Graft Surgery: Can We Do Better? Lan, Nick S. R. Ali, Umar S. Yeap, Bu B. Fegan, P. Gerry Larbalestier, Robert Bell, Damon A. J Lipid Atheroscler Original Article OBJECTIVE: Patients undergoing coronary artery bypass graft (CABG) surgery remain at high cardiovascular risk; however, few studies have evaluated lipid management and attainment of lipid targets in these patients. We investigated the proportion of CABG surgery patients who attained low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (HDL-C) targets. METHODS: Data were retrospectively obtained from patients undergoing CABG surgery at an Australian tertiary hospital between February 2015 and August 2020. The most recent lipid profile was recorded (at least 3 weeks post-operatively). We studied patients with electronically available data to ensure accuracy. Target LDL-C was defined as <1.4 (54 mg/dL) and <1.8 mmol/L (70 mg/dL), and target non-HDL-C as <2.2 (85 mg/dL) and <2.6 mmol/L (100 mg/dL), as per the 2019 and 2016 European dyslipidaemia guidelines, respectively. RESULTS: Follow-up lipid results were available for 484 patients (median post-operative follow-up, 483 days; interquartile range, 177.5–938.75 days). The mean age was 62.7±10.5 years and 387 (80.1%) were male. At discharge, 469 (96.9%) patients were prescribed statins, 425 (90.6%) high-intensity. Ezetimibe was prescribed for 62 (12.8%) patients and a proprotein convertase subtilisin-kexin type 9 inhibitor for 1. LDL-C levels <1.4 and <1.8 mmol/L were attained in 118 (24.4%) and 231 (47.7%) patients, respectively, and non-HDL-C levels <2.2 and <2.6 mmol/L in 140 (28.9%) and 237 (49.0%) patients, respectively. CONCLUSION: The use of non-statin lipid-lowering therapies was limited, and many CABG surgery patients did not attain lipid targets despite high-intensity statins. Further studies are required to optimise lipid management in this very high-risk population. Korean Society of Lipidology and Atherosclerosis 2022-05 2022-04-08 /pmc/articles/PMC9133779/ /pubmed/35656149 http://dx.doi.org/10.12997/jla.2022.11.2.187 Text en Copyright © 2022 The Korean Society of Lipid and Atherosclerosis. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lan, Nick S. R. Ali, Umar S. Yeap, Bu B. Fegan, P. Gerry Larbalestier, Robert Bell, Damon A. Attainment of Lipid Targets Following Coronary Artery Bypass Graft Surgery: Can We Do Better? |
title | Attainment of Lipid Targets Following Coronary Artery Bypass Graft Surgery: Can We Do Better? |
title_full | Attainment of Lipid Targets Following Coronary Artery Bypass Graft Surgery: Can We Do Better? |
title_fullStr | Attainment of Lipid Targets Following Coronary Artery Bypass Graft Surgery: Can We Do Better? |
title_full_unstemmed | Attainment of Lipid Targets Following Coronary Artery Bypass Graft Surgery: Can We Do Better? |
title_short | Attainment of Lipid Targets Following Coronary Artery Bypass Graft Surgery: Can We Do Better? |
title_sort | attainment of lipid targets following coronary artery bypass graft surgery: can we do better? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133779/ https://www.ncbi.nlm.nih.gov/pubmed/35656149 http://dx.doi.org/10.12997/jla.2022.11.2.187 |
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