Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response

Microbiota alteration and IFN-γ–producing CD4(+) T cell overactivation are implicated in Crohn’s disease (CD) pathogenesis. However, it remains unclear how dysbiosis enhances Th1 responses, leading to intestinal inflammation. Here, we identified key metabolites derived from dysbiotic microbiota that...

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Detalles Bibliográficos
Autores principales: Otake-Kasamoto, Yuriko, Kayama, Hisako, Kishikawa, Toshihiro, Shinzaki, Shinichiro, Tashiro, Taku, Amano, Takahiro, Tani, Mizuki, Yoshihara, Takeo, Li, Bo, Tani, Haruka, Liu, Li, Hayashi, Akio, Okuzaki, Daisuke, Motooka, Daisuke, Nakamura, Shota, Okada, Yukinori, Iijima, Hideki, Takeda, Kiyoshi, Takehara, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134096/
https://www.ncbi.nlm.nih.gov/pubmed/35608941
http://dx.doi.org/10.1084/jem.20211291

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