Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication

We studied the effect of antiviral agent riamilovir on ADP-induced platelet aggregation in the absence and presence of LPS. Unlike acetylsalicylic acid (reference drug), riamilovir did not exhibit antiplatelet effect in vitro. However, it markedly suppressed platelet reactivity in LPS-treated blood...

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Detalles Bibliográficos
Autores principales: Spasov, A. A., Kucheryavenko, A. F., Sirotenko, V. S., Gaidukova, K. A., Uskov, G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134143/
https://www.ncbi.nlm.nih.gov/pubmed/35616790
http://dx.doi.org/10.1007/s10517-022-05489-0
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author Spasov, A. A.
Kucheryavenko, A. F.
Sirotenko, V. S.
Gaidukova, K. A.
Uskov, G. M.
author_facet Spasov, A. A.
Kucheryavenko, A. F.
Sirotenko, V. S.
Gaidukova, K. A.
Uskov, G. M.
author_sort Spasov, A. A.
collection PubMed
description We studied the effect of antiviral agent riamilovir on ADP-induced platelet aggregation in the absence and presence of LPS. Unlike acetylsalicylic acid (reference drug), riamilovir did not exhibit antiplatelet effect in vitro. However, it markedly suppressed platelet reactivity in LPS-treated blood samples and was 2.2-fold superior to acetylsalicylic acid in terms of IC(50) value. In in vivo experiments, riamilovir under conditions of hypercytokinemia blocked platelet aggregation in rats by 64%.
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spelling pubmed-91341432022-05-26 Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication Spasov, A. A. Kucheryavenko, A. F. Sirotenko, V. S. Gaidukova, K. A. Uskov, G. M. Bull Exp Biol Med Article We studied the effect of antiviral agent riamilovir on ADP-induced platelet aggregation in the absence and presence of LPS. Unlike acetylsalicylic acid (reference drug), riamilovir did not exhibit antiplatelet effect in vitro. However, it markedly suppressed platelet reactivity in LPS-treated blood samples and was 2.2-fold superior to acetylsalicylic acid in terms of IC(50) value. In in vivo experiments, riamilovir under conditions of hypercytokinemia blocked platelet aggregation in rats by 64%. Springer US 2022-05-26 2022 /pmc/articles/PMC9134143/ /pubmed/35616790 http://dx.doi.org/10.1007/s10517-022-05489-0 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Spasov, A. A.
Kucheryavenko, A. F.
Sirotenko, V. S.
Gaidukova, K. A.
Uskov, G. M.
Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication
title Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication
title_full Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication
title_fullStr Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication
title_full_unstemmed Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication
title_short Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication
title_sort antiplatelet activity of riamilovir under conditions of lipopolysaccharide intoxication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134143/
https://www.ncbi.nlm.nih.gov/pubmed/35616790
http://dx.doi.org/10.1007/s10517-022-05489-0
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