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Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice

Obesity is becoming a major public health problem worldwide. Making charcoal from wood (“Sumi-yaki”) has been a traditional activity in the southern part of Nagano Prefecture for centuries, with activated charcoal having reported detoxifying effects. However, it is unclear whether activated charcoal...

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Autores principales: Zhang, Xuguang, Diao, Pan, Yokoyama, Hiroaki, Inoue, Yoshiki, Tanabe, Kazuhiro, Wang, Xiaojing, Hayashi, Chihiro, Yokoyama, Tomoki, Zhang, Zhe, Hu, Xiao, Nakajima, Takero, Kimura, Takefumi, Nakayama, Jun, Nakamuta, Makoto, Tanaka, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134190/
https://www.ncbi.nlm.nih.gov/pubmed/35634388
http://dx.doi.org/10.3389/fnut.2022.852767
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author Zhang, Xuguang
Diao, Pan
Yokoyama, Hiroaki
Inoue, Yoshiki
Tanabe, Kazuhiro
Wang, Xiaojing
Hayashi, Chihiro
Yokoyama, Tomoki
Zhang, Zhe
Hu, Xiao
Nakajima, Takero
Kimura, Takefumi
Nakayama, Jun
Nakamuta, Makoto
Tanaka, Naoki
author_facet Zhang, Xuguang
Diao, Pan
Yokoyama, Hiroaki
Inoue, Yoshiki
Tanabe, Kazuhiro
Wang, Xiaojing
Hayashi, Chihiro
Yokoyama, Tomoki
Zhang, Zhe
Hu, Xiao
Nakajima, Takero
Kimura, Takefumi
Nakayama, Jun
Nakamuta, Makoto
Tanaka, Naoki
author_sort Zhang, Xuguang
collection PubMed
description Obesity is becoming a major public health problem worldwide. Making charcoal from wood (“Sumi-yaki”) has been a traditional activity in the southern part of Nagano Prefecture for centuries, with activated charcoal having reported detoxifying effects. However, it is unclear whether activated charcoal also possesses anti-obesity properties. Additionally, since activated charcoal is usually alkaline and might be affected by gastric juice, we evaluated the effect of acidic activated charcoal on high-fat diet (HFD)-induced obesity. This study demonstrated that co-treatment of acidic activated charcoal with a HFD significantly improved obesity and insulin resistance in mice in a dose-dependent manner. Metabolomic analysis of cecal contents revealed that neutral lipids, cholesterol, and bile acids were excreted at markedly higher levels in feces with charcoal treatment. Moreover, the hepatic expressions of genes encoding cholesterol 7 alpha-hydroxylase and hydroxymethylglutaryl-CoA reductase/synthase 1 were up-regulated by activated charcoal, likely reflecting the enhanced excretions from the intestine and the enterohepatic circulation of cholesterol and bile acids. No damage or abnormalities were detected in the gastrointestinal tract, liver, pancreas, and lung. In conclusion, acidic activated charcoal may be able to attenuate HFD-induced weight gain and insulin resistance without serious adverse effects. These findings indicate a novel function of charcoal to prevent obesity, metabolic syndrome, and related diseases.
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spelling pubmed-91341902022-05-27 Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice Zhang, Xuguang Diao, Pan Yokoyama, Hiroaki Inoue, Yoshiki Tanabe, Kazuhiro Wang, Xiaojing Hayashi, Chihiro Yokoyama, Tomoki Zhang, Zhe Hu, Xiao Nakajima, Takero Kimura, Takefumi Nakayama, Jun Nakamuta, Makoto Tanaka, Naoki Front Nutr Nutrition Obesity is becoming a major public health problem worldwide. Making charcoal from wood (“Sumi-yaki”) has been a traditional activity in the southern part of Nagano Prefecture for centuries, with activated charcoal having reported detoxifying effects. However, it is unclear whether activated charcoal also possesses anti-obesity properties. Additionally, since activated charcoal is usually alkaline and might be affected by gastric juice, we evaluated the effect of acidic activated charcoal on high-fat diet (HFD)-induced obesity. This study demonstrated that co-treatment of acidic activated charcoal with a HFD significantly improved obesity and insulin resistance in mice in a dose-dependent manner. Metabolomic analysis of cecal contents revealed that neutral lipids, cholesterol, and bile acids were excreted at markedly higher levels in feces with charcoal treatment. Moreover, the hepatic expressions of genes encoding cholesterol 7 alpha-hydroxylase and hydroxymethylglutaryl-CoA reductase/synthase 1 were up-regulated by activated charcoal, likely reflecting the enhanced excretions from the intestine and the enterohepatic circulation of cholesterol and bile acids. No damage or abnormalities were detected in the gastrointestinal tract, liver, pancreas, and lung. In conclusion, acidic activated charcoal may be able to attenuate HFD-induced weight gain and insulin resistance without serious adverse effects. These findings indicate a novel function of charcoal to prevent obesity, metabolic syndrome, and related diseases. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9134190/ /pubmed/35634388 http://dx.doi.org/10.3389/fnut.2022.852767 Text en Copyright © 2022 Zhang, Diao, Yokoyama, Inoue, Tanabe, Wang, Hayashi, Yokoyama, Zhang, Hu, Nakajima, Kimura, Nakayama, Nakamuta and Tanaka. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zhang, Xuguang
Diao, Pan
Yokoyama, Hiroaki
Inoue, Yoshiki
Tanabe, Kazuhiro
Wang, Xiaojing
Hayashi, Chihiro
Yokoyama, Tomoki
Zhang, Zhe
Hu, Xiao
Nakajima, Takero
Kimura, Takefumi
Nakayama, Jun
Nakamuta, Makoto
Tanaka, Naoki
Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice
title Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice
title_full Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice
title_fullStr Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice
title_full_unstemmed Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice
title_short Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice
title_sort acidic activated charcoal prevents obesity and insulin resistance in high-fat diet-fed mice
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134190/
https://www.ncbi.nlm.nih.gov/pubmed/35634388
http://dx.doi.org/10.3389/fnut.2022.852767
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