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New Developments and Opportunities of Microbiota in Treating Breast Cancers

Despite the prevalence of breast cancer (BC), over half of BC cases are unrelated to known risk factors, which highlights the importance of uncovering more cancer-related factors. Currently, the microbiota has been proven to be a potent modulator of the tumor environment in BC, which regulates the i...

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Autores principales: Meng, Zihui, Ye, Zixuan, Zhu, Pengrong, Zhu, Jianguo, Fang, Shuguang, Qiu, Tianzhu, Li, Yanan, Meng, Lijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134200/
https://www.ncbi.nlm.nih.gov/pubmed/35633703
http://dx.doi.org/10.3389/fmicb.2022.818793
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author Meng, Zihui
Ye, Zixuan
Zhu, Pengrong
Zhu, Jianguo
Fang, Shuguang
Qiu, Tianzhu
Li, Yanan
Meng, Lijuan
author_facet Meng, Zihui
Ye, Zixuan
Zhu, Pengrong
Zhu, Jianguo
Fang, Shuguang
Qiu, Tianzhu
Li, Yanan
Meng, Lijuan
author_sort Meng, Zihui
collection PubMed
description Despite the prevalence of breast cancer (BC), over half of BC cases are unrelated to known risk factors, which highlights the importance of uncovering more cancer-related factors. Currently, the microbiota has been proven to be a potent modulator of the tumor environment in BC, which regulates the immune balance in tumor-related networks. Through a large amount of data accumulation, the microbiota has shown many possibilities to reveal more insights into the development or control of BC. To expand the potential benefits of patients with BC, this study discusses the distribution profile and the effect mechanism of BC-related microbiota on tumors and further discusses its impact on different tumor therapies. Finally, we summarize the possibility of targeting microbiological therapies to improve BC treatment or in combination with other therapies.
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spelling pubmed-91342002022-05-27 New Developments and Opportunities of Microbiota in Treating Breast Cancers Meng, Zihui Ye, Zixuan Zhu, Pengrong Zhu, Jianguo Fang, Shuguang Qiu, Tianzhu Li, Yanan Meng, Lijuan Front Microbiol Microbiology Despite the prevalence of breast cancer (BC), over half of BC cases are unrelated to known risk factors, which highlights the importance of uncovering more cancer-related factors. Currently, the microbiota has been proven to be a potent modulator of the tumor environment in BC, which regulates the immune balance in tumor-related networks. Through a large amount of data accumulation, the microbiota has shown many possibilities to reveal more insights into the development or control of BC. To expand the potential benefits of patients with BC, this study discusses the distribution profile and the effect mechanism of BC-related microbiota on tumors and further discusses its impact on different tumor therapies. Finally, we summarize the possibility of targeting microbiological therapies to improve BC treatment or in combination with other therapies. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9134200/ /pubmed/35633703 http://dx.doi.org/10.3389/fmicb.2022.818793 Text en Copyright © 2022 Meng, Ye, Zhu, Zhu, Fang, Qiu, Li and Meng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Meng, Zihui
Ye, Zixuan
Zhu, Pengrong
Zhu, Jianguo
Fang, Shuguang
Qiu, Tianzhu
Li, Yanan
Meng, Lijuan
New Developments and Opportunities of Microbiota in Treating Breast Cancers
title New Developments and Opportunities of Microbiota in Treating Breast Cancers
title_full New Developments and Opportunities of Microbiota in Treating Breast Cancers
title_fullStr New Developments and Opportunities of Microbiota in Treating Breast Cancers
title_full_unstemmed New Developments and Opportunities of Microbiota in Treating Breast Cancers
title_short New Developments and Opportunities of Microbiota in Treating Breast Cancers
title_sort new developments and opportunities of microbiota in treating breast cancers
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134200/
https://www.ncbi.nlm.nih.gov/pubmed/35633703
http://dx.doi.org/10.3389/fmicb.2022.818793
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