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Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID

BACKGROUND: Post-COVID-19 condition encompasses symptoms following COVID-19 infection that linger at least 4 weeks after the end of active infection. Symptoms are wide ranging, but breathlessness is common. PURPOSE: To determine if the previously described lung abnormalities seen on hyperpolarized (...

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Autores principales: Grist, James T., Collier, Guilhem J., Walters, Huw, Kim, Minsuok, Chen, Mitchell, Abu Eid, Gabriele, Laws, Aviana, Matthews, Violet, Jacob, Kenneth, Cross, Susan, Eves, Alexandra, Durrant, Marianne, McIntyre, Anthony, Thompson, Roger, Schulte, Rolf F., Raman, Betty, Robbins, Peter A., Wild, Jim M., Fraser, Emily, Gleeson, Fergus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Radiological Society of North America 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134268/
https://www.ncbi.nlm.nih.gov/pubmed/35608443
http://dx.doi.org/10.1148/radiol.220069
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author Grist, James T.
Collier, Guilhem J.
Walters, Huw
Kim, Minsuok
Chen, Mitchell
Abu Eid, Gabriele
Laws, Aviana
Matthews, Violet
Jacob, Kenneth
Cross, Susan
Eves, Alexandra
Durrant, Marianne
McIntyre, Anthony
Thompson, Roger
Schulte, Rolf F.
Raman, Betty
Robbins, Peter A.
Wild, Jim M.
Fraser, Emily
Gleeson, Fergus
author_facet Grist, James T.
Collier, Guilhem J.
Walters, Huw
Kim, Minsuok
Chen, Mitchell
Abu Eid, Gabriele
Laws, Aviana
Matthews, Violet
Jacob, Kenneth
Cross, Susan
Eves, Alexandra
Durrant, Marianne
McIntyre, Anthony
Thompson, Roger
Schulte, Rolf F.
Raman, Betty
Robbins, Peter A.
Wild, Jim M.
Fraser, Emily
Gleeson, Fergus
author_sort Grist, James T.
collection PubMed
description BACKGROUND: Post-COVID-19 condition encompasses symptoms following COVID-19 infection that linger at least 4 weeks after the end of active infection. Symptoms are wide ranging, but breathlessness is common. PURPOSE: To determine if the previously described lung abnormalities seen on hyperpolarized (HP) pulmonary xenon 129 ((129)Xe) MRI scans in participants with post-COVID-19 condition who were hospitalized are also present in participants with post-COVID-19 condition who were not hospitalized. MATERIALS AND METHODS: In this prospective study, nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) were enrolled from June 2020 to August 2021. Participants underwent chest CT, HP (129)Xe MRI, pulmonary function testing, and the 1-minute sit-to-stand test and completed breathlessness questionnaires. Control subjects underwent HP (129)Xe MRI only. CT scans were analyzed for post-COVID-19 interstitial lung disease severity using a previously published scoring system and full-scale airway network (FAN) modeling. Analysis used group and pairwise comparisons between participants and control subjects and correlations between participant clinical and imaging data. RESULTS: A total of 11 NHLC participants (four men, seven women; mean age, 44 years ± 11 [SD]; 95% CI: 37, 50) and 12 PHC participants (10 men, two women; mean age, 58 years ±10; 95% CI: 52, 64) were included, with a significant difference in age between groups (P = .05). Mean time from infection was 287 days ± 79 (95% CI: 240, 334) and 143 days ± 72 (95% CI: 105, 190) in NHLC and PHC participants, respectively. NHLC and PHC participants had normal or near normal CT scans (mean, 0.3/25 ± 0.6 [95% CI: 0, 0.63] and 7/25 ± 5 [95% CI: 4, 10], respectively). Gas transfer (Dlco) was different between NHLC and PHC participants (mean Dlco, 76% ± 8 [95% CI: 73, 83] vs 86% ± 8 [95% CI: 80, 91], respectively; P = .04), but there was no evidence of other differences in lung function. Mean red blood cell–to-tissue plasma ratio was different between volunteers (mean, 0.45 ± 0.07; 95% CI: 0.43, 0.47]) and PHC participants (mean, 0.31 ± 0.10; 95% CI: 0.24, 0.37; P = .02) and between volunteers and NHLC participants (mean, 0.37 ± 0.10; 95% CI: 0.31, 0.44; P = .03) but not between NHLC and PHC participants (P = .26). FAN results did not correlate with Dlco) or HP (129)Xe MRI results. CONCLUSION: Nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) showed hyperpolarized pulmonary xenon 129 MRI and red blood cell–to-tissue plasma abnormalities, with NHLC participants demonstrating lower gas transfer than PHC participants despite having normal CT findings. © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Parraga and Matheson in this issue.
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spelling pubmed-91342682022-05-27 Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID Grist, James T. Collier, Guilhem J. Walters, Huw Kim, Minsuok Chen, Mitchell Abu Eid, Gabriele Laws, Aviana Matthews, Violet Jacob, Kenneth Cross, Susan Eves, Alexandra Durrant, Marianne McIntyre, Anthony Thompson, Roger Schulte, Rolf F. Raman, Betty Robbins, Peter A. Wild, Jim M. Fraser, Emily Gleeson, Fergus Radiology Original Research BACKGROUND: Post-COVID-19 condition encompasses symptoms following COVID-19 infection that linger at least 4 weeks after the end of active infection. Symptoms are wide ranging, but breathlessness is common. PURPOSE: To determine if the previously described lung abnormalities seen on hyperpolarized (HP) pulmonary xenon 129 ((129)Xe) MRI scans in participants with post-COVID-19 condition who were hospitalized are also present in participants with post-COVID-19 condition who were not hospitalized. MATERIALS AND METHODS: In this prospective study, nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) were enrolled from June 2020 to August 2021. Participants underwent chest CT, HP (129)Xe MRI, pulmonary function testing, and the 1-minute sit-to-stand test and completed breathlessness questionnaires. Control subjects underwent HP (129)Xe MRI only. CT scans were analyzed for post-COVID-19 interstitial lung disease severity using a previously published scoring system and full-scale airway network (FAN) modeling. Analysis used group and pairwise comparisons between participants and control subjects and correlations between participant clinical and imaging data. RESULTS: A total of 11 NHLC participants (four men, seven women; mean age, 44 years ± 11 [SD]; 95% CI: 37, 50) and 12 PHC participants (10 men, two women; mean age, 58 years ±10; 95% CI: 52, 64) were included, with a significant difference in age between groups (P = .05). Mean time from infection was 287 days ± 79 (95% CI: 240, 334) and 143 days ± 72 (95% CI: 105, 190) in NHLC and PHC participants, respectively. NHLC and PHC participants had normal or near normal CT scans (mean, 0.3/25 ± 0.6 [95% CI: 0, 0.63] and 7/25 ± 5 [95% CI: 4, 10], respectively). Gas transfer (Dlco) was different between NHLC and PHC participants (mean Dlco, 76% ± 8 [95% CI: 73, 83] vs 86% ± 8 [95% CI: 80, 91], respectively; P = .04), but there was no evidence of other differences in lung function. Mean red blood cell–to-tissue plasma ratio was different between volunteers (mean, 0.45 ± 0.07; 95% CI: 0.43, 0.47]) and PHC participants (mean, 0.31 ± 0.10; 95% CI: 0.24, 0.37; P = .02) and between volunteers and NHLC participants (mean, 0.37 ± 0.10; 95% CI: 0.31, 0.44; P = .03) but not between NHLC and PHC participants (P = .26). FAN results did not correlate with Dlco) or HP (129)Xe MRI results. CONCLUSION: Nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) showed hyperpolarized pulmonary xenon 129 MRI and red blood cell–to-tissue plasma abnormalities, with NHLC participants demonstrating lower gas transfer than PHC participants despite having normal CT findings. © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Parraga and Matheson in this issue. Radiological Society of North America 2022-05-24 /pmc/articles/PMC9134268/ /pubmed/35608443 http://dx.doi.org/10.1148/radiol.220069 Text en © 2022 by the Radiological Society of North America, Inc. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Original Research
Grist, James T.
Collier, Guilhem J.
Walters, Huw
Kim, Minsuok
Chen, Mitchell
Abu Eid, Gabriele
Laws, Aviana
Matthews, Violet
Jacob, Kenneth
Cross, Susan
Eves, Alexandra
Durrant, Marianne
McIntyre, Anthony
Thompson, Roger
Schulte, Rolf F.
Raman, Betty
Robbins, Peter A.
Wild, Jim M.
Fraser, Emily
Gleeson, Fergus
Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID
title Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID
title_full Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID
title_fullStr Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID
title_full_unstemmed Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID
title_short Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID
title_sort lung abnormalities detected with hyperpolarized (129)xe mri in patients with long covid
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134268/
https://www.ncbi.nlm.nih.gov/pubmed/35608443
http://dx.doi.org/10.1148/radiol.220069
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