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Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer’s disease, and Parkinson’s disease. While constitutive Cdk5 knoc...

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Detalles Bibliográficos
Autores principales:	Umfress, Alan, Singh, Sarbjit, Ryan, Kevin J., Chakraborti, Ayanabha, Plattner, Florian, Sonawane, Yogesh, Mallareddy, Jayapal Reddy, Acosta, Edward P., Natarajan, Amarnath, Bibb, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134315/ https://www.ncbi.nlm.nih.gov/pubmed/35645825 http://dx.doi.org/10.3389/fphar.2022.863762

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