Discovery of 9,11-Seco-Cholesterol Derivatives as Novel FXR Antagonists

[Image: see text] The farnesoid X receptor (FXR) plays an important role in the regulation of bile acid, lipid, and glucose homeostasis. Recent findings have shown that the inhibition of FXR is beneficial to improvement of related metabolic diseases and cholestasis. In the present work, 9,11-seco-ch...

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Detalles Bibliográficos
Autores principales: Zhou, Jia-Xu, Li, Cui-Na, Liu, Ya-Meng, Lin, Su-Qin, Wang, Ying, Xie, Cen, Nan, Fa-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134407/
https://www.ncbi.nlm.nih.gov/pubmed/35647433
http://dx.doi.org/10.1021/acsomega.2c01567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134407/
https://www.ncbi.nlm.nih.gov/pubmed/35647433
http://dx.doi.org/10.1021/acsomega.2c01567

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