Discovery and Anticancer Activity of Novel 1,3,4-Thiadiazole- and Aziridine-Based Indolin-2-ones via In Silico Design Followed by Supramolecular Green Synthesis

[Image: see text] Three crucial anticancer scaffolds, namely indolin-2-one, 1,3,4-thiadiazole, and aziridine, are explored to synthesize virtually screened target molecules based on the c-KIT kinase protein. The stem cell factor receptor c-KIT was selected as target because most U.S. FDA-approved re...

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Detalles Bibliográficos
Autores principales: Chaudhari, Prashant J., Bari, Sanjaykumar B., Surana, Sanjay J., Shirkhedkar, Atul A., Bonde, Chandrakant G., Khadse, Saurabh C., Ugale, Vinod G., Nagar, Akhil A., Cheke, Rameshwar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134430/
https://www.ncbi.nlm.nih.gov/pubmed/35647471
http://dx.doi.org/10.1021/acsomega.2c01198

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