Cargando…

Discovery of new therapeutic targets in ovarian cancer through identifying significantly non-mutated genes

BACKGROUND: Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are essential to tumor development could lead to new therapeutic strategies. The r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Farsi, Halema, Al-Azwani, Iman, Malek, Joel A., Chouchane, Lotfi, Rafii, Arash, Halabi, Najeeb M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134657/ https://www.ncbi.nlm.nih.gov/pubmed/35619151 http://dx.doi.org/10.1186/s12967-022-03440-5

Ejemplares similares

Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer
por: Halabi, Najeeb M., et al.
Publicado: (2016)

Correction: Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer
por: Halabi, Najeeb M., et al.
Publicado: (2016)

High-prevalence and broad spectrum of Cell Adhesion and Extracellular Matrix gene pathway mutations in epithelial ovarian cancer
por: Rafii, Arash, et al.
Publicado: (2012)

Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model
por: Touboul, Cyril, et al.
Publicado: (2013)

Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile
por: Lis, Raphael, et al.
Publicado: (2014)

Copy Number Variation Analysis of Matched Ovarian Primary Tumors and Peritoneal Metastasis
por: Malek, Joel A., et al.
Publicado: (2011)

Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes
por: Karedath, Thasni, et al.
Publicado: (2019)

Akt-activated endothelium promotes ovarian cancer proliferation through notch activation
por: Hoarau-Véchot, Jessica, et al.
Publicado: (2019)

Angiocrine endothelium: from physiology to cancer
por: Pasquier, Jennifer, et al.
Publicado: (2020)

Breast Reconstruction Combining Lipofilling and Prepectoral Prosthesis after Radiotherapy
por: Razzouk, Kais, et al.
Publicado: (2020)

VE-cadherin cleavage by ovarian cancer microparticles induces β-catenin phosphorylation in endothelial cells
por: Thawadi, Hamda Al, et al.
Publicado: (2015)

Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma
por: Ahmed, Ikhlak, et al.
Publicado: (2016)

Cell Type-Specific TGF-β Mediated EMT in 3D and 2D Models and Its Reversal by TGF-β Receptor Kinase Inhibitor in Ovarian Cancer Cell Lines
por: Al Ameri, Wafa, et al.
Publicado: (2019)

Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2
por: Chouchane, Lotfi, et al.
Publicado: (2021)

Circulating miRNAs in HER2-Positive and Triple Negative Breast Cancers: Potential Biomarkers and Therapeutic Targets
por: Gupta, Ishita, et al.
Publicado: (2020)

STXBP6, reciprocally regulated with autophagy, reduces triple negative breast cancer aggressiveness
por: Lenka, Govinda, et al.
Publicado: (2020)

Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche
por: Ghiabi, Pegah, et al.
Publicado: (2015)

Activated protein C upregulates ovarian cancer cell migration and promotes unclottability of the cancer cell microenvironment
por: ALTHAWADI, HAMDA, et al.
Publicado: (2015)

Genome sequencing unveils mutational landscape of the familial Mediterranean fever: Potential implications of IL33/ST2 signalling
por: Umar, Meenakshi, et al.
Publicado: (2020)

Mesenchymal Cell Interaction with Ovarian Cancer Cells Triggers Pro-Metastatic Properties
por: Lis, Raphael, et al.
Publicado: (2012)

Comprehensive Characterization of Mesenchymal Stem Cells from Human Placenta and Fetal Membrane and Their Response to Osteoactivin Stimulation
por: Raynaud, C. M., et al.
Publicado: (2012)

Epstein–Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial–Mesenchymal Transition and Cancer Progression
por: Cyprian, Farhan S., et al.
Publicado: (2018)

Human Embryonic Stem Cell Derived Mesenchymal Progenitors Express Cardiac Markers but Do Not Form Contractile Cardiomyocytes
por: Raynaud, Christophe M., et al.
Publicado: (2013)

Role of the Microenvironment in Ovarian Cancer Stem Cell Maintenance
por: Pasquier, Jennifer, et al.
Publicado: (2013)

Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype
por: Allouch, Soumaya, et al.
Publicado: (2020)

Exome Sequencing of Only Seven Qataris Identifies Potentially Deleterious Variants in the Qatari Population
por: Rodriguez-Flores, Juan L., et al.
Publicado: (2012)

Plasma endothelial protein C receptor influences innate immune response in ovarian cancer by decreasing the population of natural killer and TH17 helper cells
por: AZZAZENE, DALEL, et al.
Publicado: ( 201)

Gene expression analysis of matched ovarian primary tumors and peritoneal metastasis
por: Malek, Joel A, et al.
Publicado: (2012)

Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells
por: Fouzat, Arij, et al.
Publicado: (2022)

Prostate cancer small non-coding RNA transcriptome in Arabs
por: Shan, Jingxuan, et al.
Publicado: (2017)

Endothelial protein C receptor expressed by ovarian cancer cells as a possible biomarker of cancer onset
por: DUCROS, ELODIE, et al.
Publicado: (2012)

A de novo synonymous variant in EFTUD2 disrupts normal splicing and causes mandibulofacial dysostosis with microcephaly: case report
por: Jacob, Arthur, et al.
Publicado: (2020)

Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells
por: Jabeen, Ayesha, et al.
Publicado: (2020)

Novel Nitrogen-Based Chalcone Analogs Provoke Substantial Apoptosis in HER2-Positive Human Breast Cancer Cells via JNK and ERK1/ERK2 Signaling Pathways
por: Rizeq, Balsam, et al.
Publicado: (2021)

Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity
por: Gupta, Ishita, et al.
Publicado: (2019)

HyperModules: identifying clinically and phenotypically significant network modules with disease mutations for biomarker discovery
por: Leung, Alvin, et al.
Publicado: (2014)

Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer
por: Gupta, Ishita, et al.
Publicado: (2021)

Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer
por: Sareyeldin, Rasha M., et al.
Publicado: (2019)

Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar
por: Gupta, Ishita, et al.
Publicado: (2022)

Evaluating the clinical significance of FLT3 mutation status in Syrian newly diagnosed acute myeloid leukemia patients with normal karyotype
por: Moualla, Yahia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lfdkd6utdrik9ee85csrdv79lt