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PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN

BACKGROUND: PIK3CA mutation and PTEN suppression lead to tumorigenesis and drug resistance in colorectal cancer (CRC). There is no research on the role of circular RNAs (circRNAs) in regulating PIK3CA mutation and MEK inhibitor resistance in CRC. METHODS: The expression of circLHFPL2 in PIK3CA-mutan...

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Detalles Bibliográficos
Autores principales:	Chong, Xiaodan, Chen, Jingde, Zheng, Nanxin, Zhou, Zhuqing, Hai, Yanan, Chen, Shiqing, Zhang, Yu, Yu, Qingzhuo, Yu, Shijun, Chen, Zhiqin, Bao, Wenfang, Quan, Ming, Chen, Zhe-Sheng, Zhan, Yangyang, Gao, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134670/ https://www.ncbi.nlm.nih.gov/pubmed/35619132 http://dx.doi.org/10.1186/s12943-022-01531-x

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