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Simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population
BACKGROUND: There is a growing concern on how to increase tuberculosis (TB) case detection in resource-poor settings. The healthcare facilities routinely providing services to the elderly for chronic diseases often failed to detect TB cases, causing a missed opportunity. This study aimed to develop...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134673/ https://www.ncbi.nlm.nih.gov/pubmed/35619084 http://dx.doi.org/10.1186/s12890-022-02001-2 |
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author | Hidayat, Agus Murti, Bhisma Soedarsono, Soedarsono Harsini Wahyuni, Chatarina Umbul Qodrijati, Isna |
author_facet | Hidayat, Agus Murti, Bhisma Soedarsono, Soedarsono Harsini Wahyuni, Chatarina Umbul Qodrijati, Isna |
author_sort | Hidayat, Agus |
collection | PubMed |
description | BACKGROUND: There is a growing concern on how to increase tuberculosis (TB) case detection in resource-poor settings. The healthcare facilities routinely providing services to the elderly for chronic diseases often failed to detect TB cases, causing a missed opportunity. This study aimed to develop a simple and sensitive screening tool using signs, symptoms, and risk factors for TB case detection in the elderly. METHODS: This was a cross-sectional study conducted from August to December 2020. A random sample of 302 subjects was taken from the elderly aged ≥ 60 years attending the outpatient polyclinic at Mangunharjo hospital, Madiun, East Java, Indonesia, for a chronic disease problem. The test was developed using 16 TB signs, symptoms, and risk factors. Test performance was assessed by comparing it against the GeneXpert MTB/RIF. RESULTS: Marginal analysis resulted in the optimal cut-point of ≥ 7 for the test, which gave an area under the curve (AUC) of 0.62, with the maximum marginal AUC of 0.04 (p < 0.001). The sensitivity and specificity were 60.26% and 64.29%, meaning 60 TB cases for every 100 elderly with TB would be otherwise left undetected if this screening test did not take place. CONCLUSION: A simple TB screening tool with moderate sensitivity and AUC has been developed using TB signs, symptoms, and risk factors. It can be used as an initial step of the systematic TB screening in the elderly visiting healthcare facilities for routine chronic disease examination, with the additional utility of reducing the missed opportunity. |
format | Online Article Text |
id | pubmed-9134673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91346732022-05-27 Simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population Hidayat, Agus Murti, Bhisma Soedarsono, Soedarsono Harsini Wahyuni, Chatarina Umbul Qodrijati, Isna BMC Pulm Med Research BACKGROUND: There is a growing concern on how to increase tuberculosis (TB) case detection in resource-poor settings. The healthcare facilities routinely providing services to the elderly for chronic diseases often failed to detect TB cases, causing a missed opportunity. This study aimed to develop a simple and sensitive screening tool using signs, symptoms, and risk factors for TB case detection in the elderly. METHODS: This was a cross-sectional study conducted from August to December 2020. A random sample of 302 subjects was taken from the elderly aged ≥ 60 years attending the outpatient polyclinic at Mangunharjo hospital, Madiun, East Java, Indonesia, for a chronic disease problem. The test was developed using 16 TB signs, symptoms, and risk factors. Test performance was assessed by comparing it against the GeneXpert MTB/RIF. RESULTS: Marginal analysis resulted in the optimal cut-point of ≥ 7 for the test, which gave an area under the curve (AUC) of 0.62, with the maximum marginal AUC of 0.04 (p < 0.001). The sensitivity and specificity were 60.26% and 64.29%, meaning 60 TB cases for every 100 elderly with TB would be otherwise left undetected if this screening test did not take place. CONCLUSION: A simple TB screening tool with moderate sensitivity and AUC has been developed using TB signs, symptoms, and risk factors. It can be used as an initial step of the systematic TB screening in the elderly visiting healthcare facilities for routine chronic disease examination, with the additional utility of reducing the missed opportunity. BioMed Central 2022-05-26 /pmc/articles/PMC9134673/ /pubmed/35619084 http://dx.doi.org/10.1186/s12890-022-02001-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Hidayat, Agus Murti, Bhisma Soedarsono, Soedarsono Harsini Wahyuni, Chatarina Umbul Qodrijati, Isna Simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population |
title | Simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population |
title_full | Simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population |
title_fullStr | Simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population |
title_full_unstemmed | Simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population |
title_short | Simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population |
title_sort | simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134673/ https://www.ncbi.nlm.nih.gov/pubmed/35619084 http://dx.doi.org/10.1186/s12890-022-02001-2 |
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