Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy

BACKGROUND: LncRNA AK044604 (regulator of insulin sensitivity and autophagy, Risa) and autophagy-related factors Sirt1 and GSK3β play important roles in diabetic nephropathy (DN). In this study, we sought to explore the effect of Risa on Sirt1/GSK3β-induced podocyte injury. METHODS: Diabetic db/db m...

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Detalles Bibliográficos
Autores principales: Su, Pei-Pei, Liu, Dong-Wei, Zhou, Si-Jie, Chen, Hang, Wu, Xian-Ming, Liu, Zhang-Suo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134699/
https://www.ncbi.nlm.nih.gov/pubmed/35614465
http://dx.doi.org/10.1186/s40779-022-00385-0

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