β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood–brain barrier destruction in Alzheimer’s disease

INTRODUCTION: Blood–brain barrier (BBB) dysfunction may occur at the onset of Alzheimer’s disease (AD). Pericytes are a vital part of the neurovascular unit and the BBB, acting as gatekeepers of the BBB. Amyloid β (Aβ) deposition and neurofibrillary tangles in the brain are the central pathological...

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Detalles Bibliográficos
Autores principales: Li, Jianhua, Li, Mengyu, Ge, Yangyang, Chen, Jiayi, Ma, Jiamin, Wang, Chenchen, Sun, Miaomiao, Wang, Li, Yao, Shanglong, Yao, Chengye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134700/
https://www.ncbi.nlm.nih.gov/pubmed/35619150
http://dx.doi.org/10.1186/s13578-022-00807-5

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