Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series

BACKGROUND: There has been an anecdotal increase in the incidence of tracheal stenosis that has coincided with the SARS-CoV-2 pandemic. CASE PRESENTATION: This is a case series in which we report clinical and pathologic findings of two patients who subsequently developed subglottic tracheal stenosis...

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Detalles Bibliográficos
Autores principales: Draeger, Tyler B., Tedesco, Sarah, Andaz, Shahriyour K., Gibson, Vanessa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134720/
https://www.ncbi.nlm.nih.gov/pubmed/35619186
http://dx.doi.org/10.1186/s13019-022-01839-1
Descripción
Sumario:BACKGROUND: There has been an anecdotal increase in the incidence of tracheal stenosis that has coincided with the SARS-CoV-2 pandemic. CASE PRESENTATION: This is a case series in which we report clinical and pathologic findings of two patients who subsequently developed subglottic tracheal stenosis after having been hospitalized with COVID-19 pneumonia. Histopathologic analysis of tissue from these patients shows features consistent with tissue infiltrated with SARS-CoV-2 virus, namely multinucleated syncytial cells with prominent nucleoli. CONCLUSION: Our findings directly implicate SARS-CoV-2 in the pathogenesis of tracheal stenosis.

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