Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series

BACKGROUND: There has been an anecdotal increase in the incidence of tracheal stenosis that has coincided with the SARS-CoV-2 pandemic. CASE PRESENTATION: This is a case series in which we report clinical and pathologic findings of two patients who subsequently developed subglottic tracheal stenosis...

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Autores principales: Draeger, Tyler B., Tedesco, Sarah, Andaz, Shahriyour K., Gibson, Vanessa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134720/
https://www.ncbi.nlm.nih.gov/pubmed/35619186
http://dx.doi.org/10.1186/s13019-022-01839-1
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author Draeger, Tyler B.
Tedesco, Sarah
Andaz, Shahriyour K.
Gibson, Vanessa R.
author_facet Draeger, Tyler B.
Tedesco, Sarah
Andaz, Shahriyour K.
Gibson, Vanessa R.
author_sort Draeger, Tyler B.
collection PubMed
description BACKGROUND: There has been an anecdotal increase in the incidence of tracheal stenosis that has coincided with the SARS-CoV-2 pandemic. CASE PRESENTATION: This is a case series in which we report clinical and pathologic findings of two patients who subsequently developed subglottic tracheal stenosis after having been hospitalized with COVID-19 pneumonia. Histopathologic analysis of tissue from these patients shows features consistent with tissue infiltrated with SARS-CoV-2 virus, namely multinucleated syncytial cells with prominent nucleoli. CONCLUSION: Our findings directly implicate SARS-CoV-2 in the pathogenesis of tracheal stenosis.
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spelling pubmed-91347202022-05-26 Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series Draeger, Tyler B. Tedesco, Sarah Andaz, Shahriyour K. Gibson, Vanessa R. J Cardiothorac Surg Case Report BACKGROUND: There has been an anecdotal increase in the incidence of tracheal stenosis that has coincided with the SARS-CoV-2 pandemic. CASE PRESENTATION: This is a case series in which we report clinical and pathologic findings of two patients who subsequently developed subglottic tracheal stenosis after having been hospitalized with COVID-19 pneumonia. Histopathologic analysis of tissue from these patients shows features consistent with tissue infiltrated with SARS-CoV-2 virus, namely multinucleated syncytial cells with prominent nucleoli. CONCLUSION: Our findings directly implicate SARS-CoV-2 in the pathogenesis of tracheal stenosis. BioMed Central 2022-05-26 /pmc/articles/PMC9134720/ /pubmed/35619186 http://dx.doi.org/10.1186/s13019-022-01839-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Draeger, Tyler B.
Tedesco, Sarah
Andaz, Shahriyour K.
Gibson, Vanessa R.
Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series
title Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series
title_full Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series
title_fullStr Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series
title_full_unstemmed Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series
title_short Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series
title_sort histologic evidence of tracheal stenosis directly resulting from sars-cov-2 tissue infiltration, a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134720/
https://www.ncbi.nlm.nih.gov/pubmed/35619186
http://dx.doi.org/10.1186/s13019-022-01839-1
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