Cargando…
TBK1 Facilitates GLUT1-Dependent Glucose Consumption by suppressing mTORC1 Signaling in Colorectal Cancer Progression
Intestinal inflammation is a vital precipitating factor of colorectal cancer (CRC), but the underlying mechanisms are still elusive. TANK-binding kinase 1 (TBK1) is a core enzyme downstream of several inflammatory signals. Recent studies brought the impacts of TBK1 in malignant disease to the forefr...
Autores principales: | Zhou, Diyuan, Yao, Yizhou, Zong, Liang, Zhou, Guoqiang, Feng, Min, Chen, Junjie, Liu, Ganggang, Chen, Guoliang, Sun, Kang, Yao, Huihui, Liu, Yu, Shi, Xinyu, Zhang, Weigang, Shi, Bo, Tai, Qingliang, Wu, Guanting, Sun, Liang, Hu, Wenqing, Zhu, Xinguo, He, Songbing |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134896/ https://www.ncbi.nlm.nih.gov/pubmed/35637944 http://dx.doi.org/10.7150/ijbs.70742 |
Ejemplares similares
-
TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877
por: Antonia, Ricardo J., et al.
Publicado: (2019) -
STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathway
por: Yao, Huihui, et al.
Publicado: (2022) -
YAP promotes the proliferation and migration of colorectal cancer cells through the Glut3/AMPK signaling pathway
por: Jiang, Linhua, et al.
Publicado: (2021) -
DAB2IP decreases cell growth and migration and increases sensitivity to chemotherapeutic drugs in colorectal cancer
por: Wu, Guanting, et al.
Publicado: (2021) -
The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt
por: Tooley, Aaron Seth, et al.
Publicado: (2021)