Cargando…
Vascular function in the aging human brain during muscle exertion
To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) a...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134944/ https://www.ncbi.nlm.nih.gov/pubmed/35500246 http://dx.doi.org/10.18632/aging.204052 |
_version_ | 1784713861899747328 |
---|---|
author | Zhu, Maijian Lee, Tania Xu Yar Hsieh, Yu-Wen Lai, Li-Fan Condello, Giancarlo Donnelly, Cyril J. Smith, Marc Hamzah, Sareena Hanim Lim, Boon-Hooi Huang, Chih-Yang Chi, Nai-Fang Kuo, Chia-Hua |
author_facet | Zhu, Maijian Lee, Tania Xu Yar Hsieh, Yu-Wen Lai, Li-Fan Condello, Giancarlo Donnelly, Cyril J. Smith, Marc Hamzah, Sareena Hanim Lim, Boon-Hooi Huang, Chih-Yang Chi, Nai-Fang Kuo, Chia-Hua |
author_sort | Zhu, Maijian |
collection | PubMed |
description | To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) aged 20–88 y. The amplitude of cerebral hemodynamic fluctuation was reflected by converting 300 values of % oxygen saturation and hemoglobin of each 30-second phase to standard deviation as indicatives of brain oxygenation variability (BOV) and brain hemodynamic variability (BHV) for each participant. Both BOV (+21–72%) and BHV (+94–158%) increased during the maximal voluntary muscle exertions for all age levels (α < 0.05), suggesting an increased vascular recruitment to maintain oxygen homeostasis in the brain. Intriguingly, BHV was >100 folds for both resting and challenged conditions (α < 0.001) in >80% of adults aged above 50 y despite similar BOV compared with young age counterparts, indicating a huge cost of amplifying hemodynamic oscillation to maintain a stable oxygenation in the aging brain. Since vascular endothelial cells are short-lived, our results implicate a hemodynamic compensation to emergence of daily deficits in replacing senescent endothelial cells after age 50 y. |
format | Online Article Text |
id | pubmed-9134944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-91349442022-06-01 Vascular function in the aging human brain during muscle exertion Zhu, Maijian Lee, Tania Xu Yar Hsieh, Yu-Wen Lai, Li-Fan Condello, Giancarlo Donnelly, Cyril J. Smith, Marc Hamzah, Sareena Hanim Lim, Boon-Hooi Huang, Chih-Yang Chi, Nai-Fang Kuo, Chia-Hua Aging (Albany NY) Research Paper To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) aged 20–88 y. The amplitude of cerebral hemodynamic fluctuation was reflected by converting 300 values of % oxygen saturation and hemoglobin of each 30-second phase to standard deviation as indicatives of brain oxygenation variability (BOV) and brain hemodynamic variability (BHV) for each participant. Both BOV (+21–72%) and BHV (+94–158%) increased during the maximal voluntary muscle exertions for all age levels (α < 0.05), suggesting an increased vascular recruitment to maintain oxygen homeostasis in the brain. Intriguingly, BHV was >100 folds for both resting and challenged conditions (α < 0.001) in >80% of adults aged above 50 y despite similar BOV compared with young age counterparts, indicating a huge cost of amplifying hemodynamic oscillation to maintain a stable oxygenation in the aging brain. Since vascular endothelial cells are short-lived, our results implicate a hemodynamic compensation to emergence of daily deficits in replacing senescent endothelial cells after age 50 y. Impact Journals 2022-05-02 /pmc/articles/PMC9134944/ /pubmed/35500246 http://dx.doi.org/10.18632/aging.204052 Text en Copyright: © 2022 Zhu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zhu, Maijian Lee, Tania Xu Yar Hsieh, Yu-Wen Lai, Li-Fan Condello, Giancarlo Donnelly, Cyril J. Smith, Marc Hamzah, Sareena Hanim Lim, Boon-Hooi Huang, Chih-Yang Chi, Nai-Fang Kuo, Chia-Hua Vascular function in the aging human brain during muscle exertion |
title | Vascular function in the aging human brain during muscle exertion |
title_full | Vascular function in the aging human brain during muscle exertion |
title_fullStr | Vascular function in the aging human brain during muscle exertion |
title_full_unstemmed | Vascular function in the aging human brain during muscle exertion |
title_short | Vascular function in the aging human brain during muscle exertion |
title_sort | vascular function in the aging human brain during muscle exertion |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134944/ https://www.ncbi.nlm.nih.gov/pubmed/35500246 http://dx.doi.org/10.18632/aging.204052 |
work_keys_str_mv | AT zhumaijian vascularfunctionintheaginghumanbrainduringmuscleexertion AT leetaniaxuyar vascularfunctionintheaginghumanbrainduringmuscleexertion AT hsiehyuwen vascularfunctionintheaginghumanbrainduringmuscleexertion AT lailifan vascularfunctionintheaginghumanbrainduringmuscleexertion AT condellogiancarlo vascularfunctionintheaginghumanbrainduringmuscleexertion AT donnellycyrilj vascularfunctionintheaginghumanbrainduringmuscleexertion AT smithmarc vascularfunctionintheaginghumanbrainduringmuscleexertion AT hamzahsareenahanim vascularfunctionintheaginghumanbrainduringmuscleexertion AT limboonhooi vascularfunctionintheaginghumanbrainduringmuscleexertion AT huangchihyang vascularfunctionintheaginghumanbrainduringmuscleexertion AT chinaifang vascularfunctionintheaginghumanbrainduringmuscleexertion AT kuochiahua vascularfunctionintheaginghumanbrainduringmuscleexertion |