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Vascular function in the aging human brain during muscle exertion

To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) a...

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Autores principales: Zhu, Maijian, Lee, Tania Xu Yar, Hsieh, Yu-Wen, Lai, Li-Fan, Condello, Giancarlo, Donnelly, Cyril J., Smith, Marc, Hamzah, Sareena Hanim, Lim, Boon-Hooi, Huang, Chih-Yang, Chi, Nai-Fang, Kuo, Chia-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134944/
https://www.ncbi.nlm.nih.gov/pubmed/35500246
http://dx.doi.org/10.18632/aging.204052
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author Zhu, Maijian
Lee, Tania Xu Yar
Hsieh, Yu-Wen
Lai, Li-Fan
Condello, Giancarlo
Donnelly, Cyril J.
Smith, Marc
Hamzah, Sareena Hanim
Lim, Boon-Hooi
Huang, Chih-Yang
Chi, Nai-Fang
Kuo, Chia-Hua
author_facet Zhu, Maijian
Lee, Tania Xu Yar
Hsieh, Yu-Wen
Lai, Li-Fan
Condello, Giancarlo
Donnelly, Cyril J.
Smith, Marc
Hamzah, Sareena Hanim
Lim, Boon-Hooi
Huang, Chih-Yang
Chi, Nai-Fang
Kuo, Chia-Hua
author_sort Zhu, Maijian
collection PubMed
description To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) aged 20–88 y. The amplitude of cerebral hemodynamic fluctuation was reflected by converting 300 values of % oxygen saturation and hemoglobin of each 30-second phase to standard deviation as indicatives of brain oxygenation variability (BOV) and brain hemodynamic variability (BHV) for each participant. Both BOV (+21–72%) and BHV (+94–158%) increased during the maximal voluntary muscle exertions for all age levels (α < 0.05), suggesting an increased vascular recruitment to maintain oxygen homeostasis in the brain. Intriguingly, BHV was >100 folds for both resting and challenged conditions (α < 0.001) in >80% of adults aged above 50 y despite similar BOV compared with young age counterparts, indicating a huge cost of amplifying hemodynamic oscillation to maintain a stable oxygenation in the aging brain. Since vascular endothelial cells are short-lived, our results implicate a hemodynamic compensation to emergence of daily deficits in replacing senescent endothelial cells after age 50 y.
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spelling pubmed-91349442022-06-01 Vascular function in the aging human brain during muscle exertion Zhu, Maijian Lee, Tania Xu Yar Hsieh, Yu-Wen Lai, Li-Fan Condello, Giancarlo Donnelly, Cyril J. Smith, Marc Hamzah, Sareena Hanim Lim, Boon-Hooi Huang, Chih-Yang Chi, Nai-Fang Kuo, Chia-Hua Aging (Albany NY) Research Paper To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) aged 20–88 y. The amplitude of cerebral hemodynamic fluctuation was reflected by converting 300 values of % oxygen saturation and hemoglobin of each 30-second phase to standard deviation as indicatives of brain oxygenation variability (BOV) and brain hemodynamic variability (BHV) for each participant. Both BOV (+21–72%) and BHV (+94–158%) increased during the maximal voluntary muscle exertions for all age levels (α < 0.05), suggesting an increased vascular recruitment to maintain oxygen homeostasis in the brain. Intriguingly, BHV was >100 folds for both resting and challenged conditions (α < 0.001) in >80% of adults aged above 50 y despite similar BOV compared with young age counterparts, indicating a huge cost of amplifying hemodynamic oscillation to maintain a stable oxygenation in the aging brain. Since vascular endothelial cells are short-lived, our results implicate a hemodynamic compensation to emergence of daily deficits in replacing senescent endothelial cells after age 50 y. Impact Journals 2022-05-02 /pmc/articles/PMC9134944/ /pubmed/35500246 http://dx.doi.org/10.18632/aging.204052 Text en Copyright: © 2022 Zhu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhu, Maijian
Lee, Tania Xu Yar
Hsieh, Yu-Wen
Lai, Li-Fan
Condello, Giancarlo
Donnelly, Cyril J.
Smith, Marc
Hamzah, Sareena Hanim
Lim, Boon-Hooi
Huang, Chih-Yang
Chi, Nai-Fang
Kuo, Chia-Hua
Vascular function in the aging human brain during muscle exertion
title Vascular function in the aging human brain during muscle exertion
title_full Vascular function in the aging human brain during muscle exertion
title_fullStr Vascular function in the aging human brain during muscle exertion
title_full_unstemmed Vascular function in the aging human brain during muscle exertion
title_short Vascular function in the aging human brain during muscle exertion
title_sort vascular function in the aging human brain during muscle exertion
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134944/
https://www.ncbi.nlm.nih.gov/pubmed/35500246
http://dx.doi.org/10.18632/aging.204052
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