Cargando…

Incidence and Survival Rates for Female Malignant Germ Cell Tumors: An Institutional Review

Background Germ cell tumor survival rates have improved over the past few decades. However, there is a lack of data on survival rates and the incidence of female germ cell tumors. This study aims to determine the incidence and survival rates of female germ cell tumors in our institution. Methodology...

Descripción completa

Detalles Bibliográficos
Autores principales: Saeed Usmani, Afshan, Yasin, Iqra, Asif, Rehan B, Kahlid, Nazish, Syed, Aamir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135046/
https://www.ncbi.nlm.nih.gov/pubmed/35651446
http://dx.doi.org/10.7759/cureus.24497
_version_ 1784713883734245376
author Saeed Usmani, Afshan
Yasin, Iqra
Asif, Rehan B
Kahlid, Nazish
Syed, Aamir
author_facet Saeed Usmani, Afshan
Yasin, Iqra
Asif, Rehan B
Kahlid, Nazish
Syed, Aamir
author_sort Saeed Usmani, Afshan
collection PubMed
description Background Germ cell tumor survival rates have improved over the past few decades. However, there is a lack of data on survival rates and the incidence of female germ cell tumors. This study aims to determine the incidence and survival rates of female germ cell tumors in our institution. Methodology This retrospective cross-sectional study was carried out at Shaukat Khanum Memorial Hospital and Research Centre, and the records over 10 years, from January 2010 to December 2020 were examined. The data of 290 females with malignant germ cell tumors were selected from 1387 females with ovarian masses, and their survival records were examined. For statistical analysis, SPSS software (version 24.0; IBM Corp. Armonk, NY) was utilized. The survival analysis was determined using the Kaplan-Meier method. Results The mean age of patients was 21.45 ± 9.28 years. The mean duration of diagnosis was 4.53 ± 2.59 years. In 245 (84.5%) patients, ovarian malignancy was involved while uterine malignancy was observed in 44 (15.2%) cases and there was one (0.3%) case of cervical carcinoma. The most common stage at diagnosis of malignancy was IA (96 (33.1%)), followed by IIIC (58 (20.0%)), IV (56 (19.3%)) and IC (26 (9.0%)). Chemotherapy was given in 244 (84.1%) cases. Out of 290 cases, 26 (9.0%) had a recurrence of the tumor while 264 (91.0%) did not have a recurrence of the tumor. Out of 290 cases, 46 (15.9%) died during follow-up, 129 (44.4%) had disease-free survival while 115 (39.7%) were healthy till the end of the study. The mean duration of survival was 3.56 ± 2.33 years. When patients' survival was compared between treatment groups, patients who did not receive chemotherapy fared better than those who did. Conclusion Female germ cell tumor patients have a good overall survival rate of more than 20% after 10 years of follow-up with effective adjuvant therapy and conservative surgery. However, more research is needed to determine the long-term effects of chemotherapy on ovarian function.
format Online
Article
Text
id pubmed-9135046
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-91350462022-05-31 Incidence and Survival Rates for Female Malignant Germ Cell Tumors: An Institutional Review Saeed Usmani, Afshan Yasin, Iqra Asif, Rehan B Kahlid, Nazish Syed, Aamir Cureus Obstetrics/Gynecology Background Germ cell tumor survival rates have improved over the past few decades. However, there is a lack of data on survival rates and the incidence of female germ cell tumors. This study aims to determine the incidence and survival rates of female germ cell tumors in our institution. Methodology This retrospective cross-sectional study was carried out at Shaukat Khanum Memorial Hospital and Research Centre, and the records over 10 years, from January 2010 to December 2020 were examined. The data of 290 females with malignant germ cell tumors were selected from 1387 females with ovarian masses, and their survival records were examined. For statistical analysis, SPSS software (version 24.0; IBM Corp. Armonk, NY) was utilized. The survival analysis was determined using the Kaplan-Meier method. Results The mean age of patients was 21.45 ± 9.28 years. The mean duration of diagnosis was 4.53 ± 2.59 years. In 245 (84.5%) patients, ovarian malignancy was involved while uterine malignancy was observed in 44 (15.2%) cases and there was one (0.3%) case of cervical carcinoma. The most common stage at diagnosis of malignancy was IA (96 (33.1%)), followed by IIIC (58 (20.0%)), IV (56 (19.3%)) and IC (26 (9.0%)). Chemotherapy was given in 244 (84.1%) cases. Out of 290 cases, 26 (9.0%) had a recurrence of the tumor while 264 (91.0%) did not have a recurrence of the tumor. Out of 290 cases, 46 (15.9%) died during follow-up, 129 (44.4%) had disease-free survival while 115 (39.7%) were healthy till the end of the study. The mean duration of survival was 3.56 ± 2.33 years. When patients' survival was compared between treatment groups, patients who did not receive chemotherapy fared better than those who did. Conclusion Female germ cell tumor patients have a good overall survival rate of more than 20% after 10 years of follow-up with effective adjuvant therapy and conservative surgery. However, more research is needed to determine the long-term effects of chemotherapy on ovarian function. Cureus 2022-04-26 /pmc/articles/PMC9135046/ /pubmed/35651446 http://dx.doi.org/10.7759/cureus.24497 Text en Copyright © 2022, Saeed Usmani et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Obstetrics/Gynecology
Saeed Usmani, Afshan
Yasin, Iqra
Asif, Rehan B
Kahlid, Nazish
Syed, Aamir
Incidence and Survival Rates for Female Malignant Germ Cell Tumors: An Institutional Review
title Incidence and Survival Rates for Female Malignant Germ Cell Tumors: An Institutional Review
title_full Incidence and Survival Rates for Female Malignant Germ Cell Tumors: An Institutional Review
title_fullStr Incidence and Survival Rates for Female Malignant Germ Cell Tumors: An Institutional Review
title_full_unstemmed Incidence and Survival Rates for Female Malignant Germ Cell Tumors: An Institutional Review
title_short Incidence and Survival Rates for Female Malignant Germ Cell Tumors: An Institutional Review
title_sort incidence and survival rates for female malignant germ cell tumors: an institutional review
topic Obstetrics/Gynecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135046/
https://www.ncbi.nlm.nih.gov/pubmed/35651446
http://dx.doi.org/10.7759/cureus.24497
work_keys_str_mv AT saeedusmaniafshan incidenceandsurvivalratesforfemalemalignantgermcelltumorsaninstitutionalreview
AT yasiniqra incidenceandsurvivalratesforfemalemalignantgermcelltumorsaninstitutionalreview
AT asifrehanb incidenceandsurvivalratesforfemalemalignantgermcelltumorsaninstitutionalreview
AT kahlidnazish incidenceandsurvivalratesforfemalemalignantgermcelltumorsaninstitutionalreview
AT syedaamir incidenceandsurvivalratesforfemalemalignantgermcelltumorsaninstitutionalreview