Use of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIα intron-19 5’ splice site: Generation of etoposide resistance in human leukemia K562 cells

DNA Topoisomerase IIα (TOP2α/170) is an enzyme essential for proliferating cells. For rapidly multiplying malignancies, this has made TOP2α/170 an important target for etoposide and other clinically active anticancer drugs. Efficacy of these agents is often limited by chemoresistance related to alte...

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Detalles Bibliográficos
Autores principales: Hernandez, Victor A., Carvajal-Moreno, Jessika, Wang, Xinyi, Pietrzak, Maciej, Yalowich, Jack C., Elton, Terry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135202/
https://www.ncbi.nlm.nih.gov/pubmed/35617303
http://dx.doi.org/10.1371/journal.pone.0265794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135202/
https://www.ncbi.nlm.nih.gov/pubmed/35617303
http://dx.doi.org/10.1371/journal.pone.0265794

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