Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk

Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be associated with Alzheimer disease (AD) risk in cognit...

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Detalles Bibliográficos
Autores principales: Ali, Muhammad, Sung, Yun Ju, Wang, Fengxian, Fernández, Maria V., Morris, John C., Fagan, Anne M., Blennow, Kaj, Zetterberg, Henrik, Heslegrave, Amanda, Johansson, Per M., Svensson, Johan, Nellgård, Bengt, Lleó, Alberto, Alcolea, Daniel, Clarimon, Jordi, Rami, Lorena, Molinuevo, José Luis, Suárez-Calvet, Marc, Morenas-Rodríguez, Estrella, Kleinberger, Gernot, Haass, Christian, Ewers, Michael, Levin, Johannes, Farlow, Martin R., Perrin, Richard J., Cruchaga, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135221/
https://www.ncbi.nlm.nih.gov/pubmed/35617280
http://dx.doi.org/10.1371/journal.pone.0267298

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