Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program

Ehrlichia chaffeensis (E. chaffeensis) has evolved eukaryotic ligand mimicry to repurpose multiple cellular signaling pathways for immune evasion. In this investigation, we demonstrate that TRP120 has a novel repetitive short linear motif (SLiM) that activates the evolutionarily conserved Hedgehog (...

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Detalles Bibliográficos
Autores principales: Byerly, Caitlan D., Mitra, Shubhajit, Patterson, LaNisha L., Pittner, Nicholas A., Velayutham, Thangam S., Paessler, Slobodan, Veljkovic, Veljko, McBride, Jere W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135340/
https://www.ncbi.nlm.nih.gov/pubmed/35576232
http://dx.doi.org/10.1371/journal.ppat.1010345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135340/
https://www.ncbi.nlm.nih.gov/pubmed/35576232
http://dx.doi.org/10.1371/journal.ppat.1010345

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