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Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data
To infer a causal relationship between two traits, several correlation-based causal direction (CD) methods have been proposed with the use of SNPs as instrumental variables (IVs) based on GWAS summary data for the two traits; however, none of the existing CD methods can deal with SNPs with correlate...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135345/ https://www.ncbi.nlm.nih.gov/pubmed/35576237 http://dx.doi.org/10.1371/journal.pgen.1010205 |