Binary outcomes of enhancer activity underlie stable random monoallelic expression

Mitotically stable random monoallelic gene expression (RME) is documented for a small percentage of autosomal genes. We developed an in vivo genetic model to study the role of enhancers in RME using high-resolution single-cell analysis of natural killer (NK) cell receptor gene expression and enhance...

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Detalles Bibliográficos
Autores principales: Kissiov, Djem U, Ethell, Alexander, Chen, Sean, Wolf, Natalie K, Zhang, Chenyu, Dang, Susanna M, Jo, Yeara, Madsen, Katrine N, Paranjpe, Ishan, Lee, Angus Y, Chim, Bryan, Muljo, Stefan A, Raulet, David H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135403/
https://www.ncbi.nlm.nih.gov/pubmed/35617021
http://dx.doi.org/10.7554/eLife.74204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135403/
https://www.ncbi.nlm.nih.gov/pubmed/35617021
http://dx.doi.org/10.7554/eLife.74204

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