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ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress

Testicular torsion-detorsion is an ischaemia-reperfusion-induced male gonad injury that may lead to male infertility. Oxidative stress plays an important role in the ischaemia-reperfusion injury. Icariside II (ICA II) prevents oxidative stress and has obvious protective effects on spermatogenic func...

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Autores principales: Chi, Ani, Yang, Bicheng, Cao, Xiaohui, Wang, Zhenqing, Liu, Hanchao, Dai, Hao, Deng, Chunhua, Zhang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135456/
https://www.ncbi.nlm.nih.gov/pubmed/35634492
http://dx.doi.org/10.3389/fendo.2022.871548
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author Chi, Ani
Yang, Bicheng
Cao, Xiaohui
Wang, Zhenqing
Liu, Hanchao
Dai, Hao
Deng, Chunhua
Zhang, Min
author_facet Chi, Ani
Yang, Bicheng
Cao, Xiaohui
Wang, Zhenqing
Liu, Hanchao
Dai, Hao
Deng, Chunhua
Zhang, Min
author_sort Chi, Ani
collection PubMed
description Testicular torsion-detorsion is an ischaemia-reperfusion-induced male gonad injury that may lead to male infertility. Oxidative stress plays an important role in the ischaemia-reperfusion injury. Icariside II (ICA II) prevents oxidative stress and has obvious protective effects on spermatogenic function. The present study was aimed to investigate therapeutic potentials of ICA II on testicular torsion. 72 mice were randomly divided into three groups: sham-operated control group (n = 24), testicular ischemia-reperfusion + saline group (n = 24) and testicular ischemia-reperfusion + icariside II treated group (n = 24). Testicular ischemia-reperfusion was induced by the left testis rotated 360 degrees in a clockwise direction for 30 minutes followed by detorsion, the contralateral testis was removed. ICA II in saline (5 mg/kg/day) was administrated by gavage immediately after detorsion. The results demonstrated that ICA II alleviated testicular damage by mitigating spermatogenic cell injury and improving testosterone production in mouse models of testicular torsion. We revealed that ICA II alleviated oxidative stress and apoptosis in the testes, reduced inflammatory infiltration and accelerated angiogenesis. Briefly, ICA II administration ameliorated testicular damage by improving spermatogenic function and testosterone production, which supports its use as a pharmacological treatment of testicular torsion.
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spelling pubmed-91354562022-05-27 ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress Chi, Ani Yang, Bicheng Cao, Xiaohui Wang, Zhenqing Liu, Hanchao Dai, Hao Deng, Chunhua Zhang, Min Front Endocrinol (Lausanne) Endocrinology Testicular torsion-detorsion is an ischaemia-reperfusion-induced male gonad injury that may lead to male infertility. Oxidative stress plays an important role in the ischaemia-reperfusion injury. Icariside II (ICA II) prevents oxidative stress and has obvious protective effects on spermatogenic function. The present study was aimed to investigate therapeutic potentials of ICA II on testicular torsion. 72 mice were randomly divided into three groups: sham-operated control group (n = 24), testicular ischemia-reperfusion + saline group (n = 24) and testicular ischemia-reperfusion + icariside II treated group (n = 24). Testicular ischemia-reperfusion was induced by the left testis rotated 360 degrees in a clockwise direction for 30 minutes followed by detorsion, the contralateral testis was removed. ICA II in saline (5 mg/kg/day) was administrated by gavage immediately after detorsion. The results demonstrated that ICA II alleviated testicular damage by mitigating spermatogenic cell injury and improving testosterone production in mouse models of testicular torsion. We revealed that ICA II alleviated oxidative stress and apoptosis in the testes, reduced inflammatory infiltration and accelerated angiogenesis. Briefly, ICA II administration ameliorated testicular damage by improving spermatogenic function and testosterone production, which supports its use as a pharmacological treatment of testicular torsion. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9135456/ /pubmed/35634492 http://dx.doi.org/10.3389/fendo.2022.871548 Text en Copyright © 2022 Chi, Yang, Cao, Wang, Liu, Dai, Deng and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Chi, Ani
Yang, Bicheng
Cao, Xiaohui
Wang, Zhenqing
Liu, Hanchao
Dai, Hao
Deng, Chunhua
Zhang, Min
ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress
title ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress
title_full ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress
title_fullStr ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress
title_full_unstemmed ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress
title_short ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress
title_sort ica ii alleviates testicular torsion injury by dampening the oxidative and inflammatory stress
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135456/
https://www.ncbi.nlm.nih.gov/pubmed/35634492
http://dx.doi.org/10.3389/fendo.2022.871548
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