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Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors
In one of the largest, most comprehensive studies on borderline personality disorder (BPD) to date, this article places into context associations between this diagnosis and (1) 16 different psychiatric disorders, (2) eight somatic illnesses, and (3) six trauma and adverse behaviors, e.g., violent cr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135625/ https://www.ncbi.nlm.nih.gov/pubmed/35304564 http://dx.doi.org/10.1038/s41380-022-01503-z |
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author | Tate, Ashley E. Sahlin, Hanna Liu, Shengxin Lu, Yi Lundström, Sebastian Larsson, Henrik Lichtenstein, Paul Kuja-Halkola, Ralf |
author_facet | Tate, Ashley E. Sahlin, Hanna Liu, Shengxin Lu, Yi Lundström, Sebastian Larsson, Henrik Lichtenstein, Paul Kuja-Halkola, Ralf |
author_sort | Tate, Ashley E. |
collection | PubMed |
description | In one of the largest, most comprehensive studies on borderline personality disorder (BPD) to date, this article places into context associations between this diagnosis and (1) 16 different psychiatric disorders, (2) eight somatic illnesses, and (3) six trauma and adverse behaviors, e.g., violent crime victimization and self-harm. Second, it examines the sex differences in individuals with BPD and their siblings. A total of 1,969,839 Swedish individuals were identified from national registers. Cumulative incidence with 95% confidence intervals (CI) was evaluated after 5 years of follow-up from BPD diagnosis and compared with a matched cohort. Associations were estimated as hazard ratios (HR) with 95% CIs from Cox regression. 12,175 individuals were diagnosed with BPD (85.3% female). Individuals diagnosed with BPD had higher cumulative incidences and HRs for nearly all analyzed indicators, especially psychiatric disorders. Anxiety disorders were most common (cumulative incidence 95% CI 33.13% [31.48–34.73]). Other notable findings from Cox regressions include psychotic disorders (HR 95% CI 24.48 [23.14–25.90]), epilepsy (3.38 [3.08–3.70]), violent crime victimization (7.65 [7.25–8.06]), and self-harm (17.72 [17.27–18.19]). HRs in males and females with BPD had overlapping CIs for nearly all indicators. This indicates that a BPD diagnosis is a marker of vulnerability for negative events and poor physical and mental health similarly for both males and females. Having a sibling with BPD was associated with an increased risk for psychiatric disorders, trauma, and adverse behaviors but not somatic disorders. Clinical implications include the need for increased support for patients with BPD navigating the health care system. |
format | Online Article Text |
id | pubmed-9135625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91356252022-05-28 Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors Tate, Ashley E. Sahlin, Hanna Liu, Shengxin Lu, Yi Lundström, Sebastian Larsson, Henrik Lichtenstein, Paul Kuja-Halkola, Ralf Mol Psychiatry Article In one of the largest, most comprehensive studies on borderline personality disorder (BPD) to date, this article places into context associations between this diagnosis and (1) 16 different psychiatric disorders, (2) eight somatic illnesses, and (3) six trauma and adverse behaviors, e.g., violent crime victimization and self-harm. Second, it examines the sex differences in individuals with BPD and their siblings. A total of 1,969,839 Swedish individuals were identified from national registers. Cumulative incidence with 95% confidence intervals (CI) was evaluated after 5 years of follow-up from BPD diagnosis and compared with a matched cohort. Associations were estimated as hazard ratios (HR) with 95% CIs from Cox regression. 12,175 individuals were diagnosed with BPD (85.3% female). Individuals diagnosed with BPD had higher cumulative incidences and HRs for nearly all analyzed indicators, especially psychiatric disorders. Anxiety disorders were most common (cumulative incidence 95% CI 33.13% [31.48–34.73]). Other notable findings from Cox regressions include psychotic disorders (HR 95% CI 24.48 [23.14–25.90]), epilepsy (3.38 [3.08–3.70]), violent crime victimization (7.65 [7.25–8.06]), and self-harm (17.72 [17.27–18.19]). HRs in males and females with BPD had overlapping CIs for nearly all indicators. This indicates that a BPD diagnosis is a marker of vulnerability for negative events and poor physical and mental health similarly for both males and females. Having a sibling with BPD was associated with an increased risk for psychiatric disorders, trauma, and adverse behaviors but not somatic disorders. Clinical implications include the need for increased support for patients with BPD navigating the health care system. Nature Publishing Group UK 2022-03-18 2022 /pmc/articles/PMC9135625/ /pubmed/35304564 http://dx.doi.org/10.1038/s41380-022-01503-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Tate, Ashley E. Sahlin, Hanna Liu, Shengxin Lu, Yi Lundström, Sebastian Larsson, Henrik Lichtenstein, Paul Kuja-Halkola, Ralf Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors |
title | Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors |
title_full | Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors |
title_fullStr | Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors |
title_full_unstemmed | Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors |
title_short | Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors |
title_sort | borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135625/ https://www.ncbi.nlm.nih.gov/pubmed/35304564 http://dx.doi.org/10.1038/s41380-022-01503-z |
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