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Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index
Aims: Elevated serum alkaline phosphatase (ALP) levels are associated with an increased risk of cerebrocardiovascular diseases. However, the associations of ALP with peripheral arterial disease (PAD) and outcomes in patients with acute ischemic stroke (AIS) are not well-known. Methods: We examined t...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Atherosclerosis Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135667/ https://www.ncbi.nlm.nih.gov/pubmed/33790143 http://dx.doi.org/10.5551/jat.62795 |
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author | Naito, Hiroyuki Nezu, Tomohisa Hosomi, Naohisa Kuzume, Daisuke Aoki, Shiro Morimoto, Yuko Yoshida, Takeshi Kamimura, Teppei Shiga, Yuji Kinoshita, Naoto Ueno, Hiroki Morino, Hiroyuki Maruyama, Hirofumi |
author_facet | Naito, Hiroyuki Nezu, Tomohisa Hosomi, Naohisa Kuzume, Daisuke Aoki, Shiro Morimoto, Yuko Yoshida, Takeshi Kamimura, Teppei Shiga, Yuji Kinoshita, Naoto Ueno, Hiroki Morino, Hiroyuki Maruyama, Hirofumi |
author_sort | Naito, Hiroyuki |
collection | PubMed |
description | Aims: Elevated serum alkaline phosphatase (ALP) levels are associated with an increased risk of cerebrocardiovascular diseases. However, the associations of ALP with peripheral arterial disease (PAD) and outcomes in patients with acute ischemic stroke (AIS) are not well-known. Methods: We examined the association between ALP levels and the ankle–brachial index (ABI) in 2111 consecutive patients with AIS. A poor functional outcome was defined as a modified Rankin Scale (mRS) score of 3–6 at 3 months after stroke. A low ABI was defined as a value of ≤ 0.9. Results: Of the total cohort, 482 patients (22.8%) had a low ABI. ALP levels were higher in patients with a low ABI than in those without (p<0.001). The multivariable logistic analysis revealed that quartiles of ALP levels were significantly associated with a low ABI (odds ratio [OR]: 1.20, 95% confidence interval [CI]: 1.08–1.33). Of the 1322 patients with a premorbid mRS score of 0–2, 434 patients (32.8%) had a poor outcome. The multivariable analysis revealed that elevated serum ALP levels and a low ABI were independently associated with poor stroke outcomes after adjustment for baseline characteristics (OR: 1.21, 95% CI: 1.07–1.38, and OR: 2.00, 95% CI: 1.40–2.84, respectively). Conclusions: Increased serum ALP levels are significantly associated with a low ABI. These indicators are independent prognostic factors for poor stroke outcomes at 3 months. |
format | Online Article Text |
id | pubmed-9135667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Japan Atherosclerosis Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-91356672022-06-04 Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index Naito, Hiroyuki Nezu, Tomohisa Hosomi, Naohisa Kuzume, Daisuke Aoki, Shiro Morimoto, Yuko Yoshida, Takeshi Kamimura, Teppei Shiga, Yuji Kinoshita, Naoto Ueno, Hiroki Morino, Hiroyuki Maruyama, Hirofumi J Atheroscler Thromb Original Article Aims: Elevated serum alkaline phosphatase (ALP) levels are associated with an increased risk of cerebrocardiovascular diseases. However, the associations of ALP with peripheral arterial disease (PAD) and outcomes in patients with acute ischemic stroke (AIS) are not well-known. Methods: We examined the association between ALP levels and the ankle–brachial index (ABI) in 2111 consecutive patients with AIS. A poor functional outcome was defined as a modified Rankin Scale (mRS) score of 3–6 at 3 months after stroke. A low ABI was defined as a value of ≤ 0.9. Results: Of the total cohort, 482 patients (22.8%) had a low ABI. ALP levels were higher in patients with a low ABI than in those without (p<0.001). The multivariable logistic analysis revealed that quartiles of ALP levels were significantly associated with a low ABI (odds ratio [OR]: 1.20, 95% confidence interval [CI]: 1.08–1.33). Of the 1322 patients with a premorbid mRS score of 0–2, 434 patients (32.8%) had a poor outcome. The multivariable analysis revealed that elevated serum ALP levels and a low ABI were independently associated with poor stroke outcomes after adjustment for baseline characteristics (OR: 1.21, 95% CI: 1.07–1.38, and OR: 2.00, 95% CI: 1.40–2.84, respectively). Conclusions: Increased serum ALP levels are significantly associated with a low ABI. These indicators are independent prognostic factors for poor stroke outcomes at 3 months. Japan Atherosclerosis Society 2022-05-01 2021-03-30 /pmc/articles/PMC9135667/ /pubmed/33790143 http://dx.doi.org/10.5551/jat.62795 Text en 2022 Japan Atherosclerosis Society https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) |
spellingShingle | Original Article Naito, Hiroyuki Nezu, Tomohisa Hosomi, Naohisa Kuzume, Daisuke Aoki, Shiro Morimoto, Yuko Yoshida, Takeshi Kamimura, Teppei Shiga, Yuji Kinoshita, Naoto Ueno, Hiroki Morino, Hiroyuki Maruyama, Hirofumi Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index |
title | Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index |
title_full | Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index |
title_fullStr | Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index |
title_full_unstemmed | Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index |
title_short | Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index |
title_sort | increased serum alkaline phosphatase and functional outcome in patients with acute ischemic stroke presenting a low ankle–brachial index |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135667/ https://www.ncbi.nlm.nih.gov/pubmed/33790143 http://dx.doi.org/10.5551/jat.62795 |
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