RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation

RNase H2 is a specialized enzyme that degrades RNA in RNA/DNA hybrids and deficiency of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutières syndrome (AGS). However, the molecular mechanism underlying AGS is still unclear. Here, we show that RNase H2 is associated with a subset o...

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Detalles Bibliográficos
Autores principales: Cristini, Agnese, Tellier, Michael, Constantinescu, Flavia, Accalai, Clelia, Albulescu, Laura Oana, Heiringhoff, Robin, Bery, Nicolas, Sordet, Olivier, Murphy, Shona, Gromak, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135716/
https://www.ncbi.nlm.nih.gov/pubmed/35618715
http://dx.doi.org/10.1038/s41467-022-30604-0

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