A topological refactoring design strategy yields highly stable granulopoietic proteins

Protein therapeutics frequently face major challenges, including complicated production, instability, poor solubility, and aggregation. De novo protein design can readily address these challenges. Here, we demonstrate the utility of a topological refactoring strategy to design novel granulopoietic p...

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Detalles Bibliográficos
Autores principales: Skokowa, Julia, Hernandez Alvarez, Birte, Coles, Murray, Ritter, Malte, Nasri, Masoud, Haaf, Jérémy, Aghaallaei, Narges, Xu, Yun, Mir, Perihan, Krahl, Ann-Christin, Rogers, Katherine W., Maksymenko, Kateryna, Bajoghli, Baubak, Welte, Karl, Lupas, Andrei N., Müller, Patrick, ElGamacy, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135769/
https://www.ncbi.nlm.nih.gov/pubmed/35618709
http://dx.doi.org/10.1038/s41467-022-30157-2

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