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Selective brain regional changes in lipid profile with human aging
Fatty acids are key components in the structural diversity of lipids and play a strategic role in the functional properties of lipids which determine the integrity of neuronal and glial cell membranes, the generation of lipid signaling mediators, and the chemical reactivity of acyl chains. The prese...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135931/ https://www.ncbi.nlm.nih.gov/pubmed/35149960 http://dx.doi.org/10.1007/s11357-022-00527-1 |
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author | Mota-Martorell, Natalia Andrés-Benito, Pol Martín-Gari, Meritxell Galo-Licona, José Daniel Sol, Joaquim Fernández-Bernal, Anna Portero-Otín, Manuel Ferrer, Isidro Jove, Mariona Pamplona, Reinald |
author_facet | Mota-Martorell, Natalia Andrés-Benito, Pol Martín-Gari, Meritxell Galo-Licona, José Daniel Sol, Joaquim Fernández-Bernal, Anna Portero-Otín, Manuel Ferrer, Isidro Jove, Mariona Pamplona, Reinald |
author_sort | Mota-Martorell, Natalia |
collection | PubMed |
description | Fatty acids are key components in the structural diversity of lipids and play a strategic role in the functional properties of lipids which determine the integrity of neuronal and glial cell membranes, the generation of lipid signaling mediators, and the chemical reactivity of acyl chains. The present study analyzes using gas chromatography the fatty acid profiles of 13 regions of the human central nervous system in healthy individuals ranging from 40 to 80 years old. The outcomes suggest the existence of general traits in fatty acid composition such as an average chain length of 18 carbon atoms, high monounsaturated fatty acid content, and predominance in polyunsaturated fatty acids of those of series n-6 over series n-3 which are shared by all brain regions regardless of age. Our results also show a general sustained and relatively well-preserved lipid profile throughout the adult lifespan in most studied regions (olive, upper vermis, substantia nigra, thalamus, hippocampus, putamen, caudate, occipital cortex, parietal cortex, entorhinal cortex, and frontal cortex) with minor changes that are region-dependent. In contrast, of particular relevance is the involvement of the inferior temporal cortex and cingulate cortex. It is proposed that during normal human brain aging, the lipid profile is resistant to changes with age in most human brain regions to ensure cell survival and function, but some particular regions involved in specific memory domains are greatly affected. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00527-1. |
format | Online Article Text |
id | pubmed-9135931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-91359312022-05-28 Selective brain regional changes in lipid profile with human aging Mota-Martorell, Natalia Andrés-Benito, Pol Martín-Gari, Meritxell Galo-Licona, José Daniel Sol, Joaquim Fernández-Bernal, Anna Portero-Otín, Manuel Ferrer, Isidro Jove, Mariona Pamplona, Reinald GeroScience Original Article Fatty acids are key components in the structural diversity of lipids and play a strategic role in the functional properties of lipids which determine the integrity of neuronal and glial cell membranes, the generation of lipid signaling mediators, and the chemical reactivity of acyl chains. The present study analyzes using gas chromatography the fatty acid profiles of 13 regions of the human central nervous system in healthy individuals ranging from 40 to 80 years old. The outcomes suggest the existence of general traits in fatty acid composition such as an average chain length of 18 carbon atoms, high monounsaturated fatty acid content, and predominance in polyunsaturated fatty acids of those of series n-6 over series n-3 which are shared by all brain regions regardless of age. Our results also show a general sustained and relatively well-preserved lipid profile throughout the adult lifespan in most studied regions (olive, upper vermis, substantia nigra, thalamus, hippocampus, putamen, caudate, occipital cortex, parietal cortex, entorhinal cortex, and frontal cortex) with minor changes that are region-dependent. In contrast, of particular relevance is the involvement of the inferior temporal cortex and cingulate cortex. It is proposed that during normal human brain aging, the lipid profile is resistant to changes with age in most human brain regions to ensure cell survival and function, but some particular regions involved in specific memory domains are greatly affected. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00527-1. Springer International Publishing 2022-02-11 /pmc/articles/PMC9135931/ /pubmed/35149960 http://dx.doi.org/10.1007/s11357-022-00527-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Mota-Martorell, Natalia Andrés-Benito, Pol Martín-Gari, Meritxell Galo-Licona, José Daniel Sol, Joaquim Fernández-Bernal, Anna Portero-Otín, Manuel Ferrer, Isidro Jove, Mariona Pamplona, Reinald Selective brain regional changes in lipid profile with human aging |
title | Selective brain regional changes in lipid profile with human aging |
title_full | Selective brain regional changes in lipid profile with human aging |
title_fullStr | Selective brain regional changes in lipid profile with human aging |
title_full_unstemmed | Selective brain regional changes in lipid profile with human aging |
title_short | Selective brain regional changes in lipid profile with human aging |
title_sort | selective brain regional changes in lipid profile with human aging |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135931/ https://www.ncbi.nlm.nih.gov/pubmed/35149960 http://dx.doi.org/10.1007/s11357-022-00527-1 |
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