Targeting the Homologous Recombination Pathway in Cancer With a Novel Class of RAD51 Inhibitors

Targeting DNA damage response (DDR) pathway has been proposed as an approach for amplifying tumor-specific replicative lesions. RAD51 plays a central role in the DDR process, and thus represents a promising anti-tumor target. We here report the discovery of a series of next generation RAD51 inhibito...

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Detalles Bibliográficos
Autores principales: Gu, Peng, Xue, Liting, Zhao, Chunyan, Li, Wenjing, Jiang, Zhen, Liu, Aiguo, Li, Tingting, Liu, Lu, Decker, Markus, Cheng, Xiaoxuan, Yang, Wenqing, Tang, Renhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136011/
https://www.ncbi.nlm.nih.gov/pubmed/35646698
http://dx.doi.org/10.3389/fonc.2022.885186

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