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Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System

The cerebellum is emerging as a powerful regulator of cognitive and affective processing and memory in both humans and animals and has been implicated in affective disorders. How the cerebellum supports affective function remains poorly understood. The short-latency (just a few milliseconds) functio...

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Autores principales: Jung, Se Jung, Vlasov, Ksenia, D’Ambra, Alexa F., Parigi, Abhijna, Baya, Mihir, Frez, Edbertt Paul, Villalobos, Jacqueline, Fernandez-Frentzel, Marina, Anguiano, Maribel, Ideguchi, Yoichiro, Antzoulatos, Evan G., Fioravante, Diasynou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136059/
https://www.ncbi.nlm.nih.gov/pubmed/35645738
http://dx.doi.org/10.3389/fnsys.2022.879634
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author Jung, Se Jung
Vlasov, Ksenia
D’Ambra, Alexa F.
Parigi, Abhijna
Baya, Mihir
Frez, Edbertt Paul
Villalobos, Jacqueline
Fernandez-Frentzel, Marina
Anguiano, Maribel
Ideguchi, Yoichiro
Antzoulatos, Evan G.
Fioravante, Diasynou
author_facet Jung, Se Jung
Vlasov, Ksenia
D’Ambra, Alexa F.
Parigi, Abhijna
Baya, Mihir
Frez, Edbertt Paul
Villalobos, Jacqueline
Fernandez-Frentzel, Marina
Anguiano, Maribel
Ideguchi, Yoichiro
Antzoulatos, Evan G.
Fioravante, Diasynou
author_sort Jung, Se Jung
collection PubMed
description The cerebellum is emerging as a powerful regulator of cognitive and affective processing and memory in both humans and animals and has been implicated in affective disorders. How the cerebellum supports affective function remains poorly understood. The short-latency (just a few milliseconds) functional connections that were identified between the cerebellum and amygdala—a structure crucial for the processing of emotion and valence—more than four decades ago raise the exciting, yet untested, possibility that a cerebellum-amygdala pathway communicates information important for emotion. The major hurdle in rigorously testing this possibility is the lack of knowledge about the anatomy and functional connectivity of this pathway. Our initial anatomical tracing studies in mice excluded the existence of a direct monosynaptic connection between the cerebellum and amygdala. Using transneuronal tracing techniques, we have identified a novel disynaptic circuit between the cerebellar output nuclei and the basolateral amygdala. This circuit recruits the understudied intralaminar thalamus as a node. Using ex vivo optophysiology and super-resolution microscopy, we provide the first evidence for the functionality of the pathway, thus offering a missing mechanistic link between the cerebellum and amygdala. This discovery provides a connectivity blueprint between the cerebellum and a key structure of the limbic system. As such, it is the requisite first step toward obtaining new knowledge about cerebellar function in emotion, thus fundamentally advancing understanding of the neurobiology of emotion, which is perturbed in mental and autism spectrum disorders.
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spelling pubmed-91360592022-05-28 Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System Jung, Se Jung Vlasov, Ksenia D’Ambra, Alexa F. Parigi, Abhijna Baya, Mihir Frez, Edbertt Paul Villalobos, Jacqueline Fernandez-Frentzel, Marina Anguiano, Maribel Ideguchi, Yoichiro Antzoulatos, Evan G. Fioravante, Diasynou Front Syst Neurosci Neuroscience The cerebellum is emerging as a powerful regulator of cognitive and affective processing and memory in both humans and animals and has been implicated in affective disorders. How the cerebellum supports affective function remains poorly understood. The short-latency (just a few milliseconds) functional connections that were identified between the cerebellum and amygdala—a structure crucial for the processing of emotion and valence—more than four decades ago raise the exciting, yet untested, possibility that a cerebellum-amygdala pathway communicates information important for emotion. The major hurdle in rigorously testing this possibility is the lack of knowledge about the anatomy and functional connectivity of this pathway. Our initial anatomical tracing studies in mice excluded the existence of a direct monosynaptic connection between the cerebellum and amygdala. Using transneuronal tracing techniques, we have identified a novel disynaptic circuit between the cerebellar output nuclei and the basolateral amygdala. This circuit recruits the understudied intralaminar thalamus as a node. Using ex vivo optophysiology and super-resolution microscopy, we provide the first evidence for the functionality of the pathway, thus offering a missing mechanistic link between the cerebellum and amygdala. This discovery provides a connectivity blueprint between the cerebellum and a key structure of the limbic system. As such, it is the requisite first step toward obtaining new knowledge about cerebellar function in emotion, thus fundamentally advancing understanding of the neurobiology of emotion, which is perturbed in mental and autism spectrum disorders. Frontiers Media S.A. 2022-05-13 /pmc/articles/PMC9136059/ /pubmed/35645738 http://dx.doi.org/10.3389/fnsys.2022.879634 Text en Copyright © 2022  Jung, Vlasov, D’Ambra, Parigi, Baya, Frez, Villalobos, Fernandez-Frentzel, Anguiano, Ideguchi, Antzoulatos and Fioravante. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jung, Se Jung
Vlasov, Ksenia
D’Ambra, Alexa F.
Parigi, Abhijna
Baya, Mihir
Frez, Edbertt Paul
Villalobos, Jacqueline
Fernandez-Frentzel, Marina
Anguiano, Maribel
Ideguchi, Yoichiro
Antzoulatos, Evan G.
Fioravante, Diasynou
Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System
title Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System
title_full Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System
title_fullStr Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System
title_full_unstemmed Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System
title_short Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System
title_sort novel cerebello-amygdala connections provide missing link between cerebellum and limbic system
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136059/
https://www.ncbi.nlm.nih.gov/pubmed/35645738
http://dx.doi.org/10.3389/fnsys.2022.879634
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