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Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review

Due to excellent mechanical properties and similar elastic modulus compared with human cortical bone, polyetheretherketone (PEEK) has become one of the most promising orthopedic implant materials. However, implant-associated infections (IAIs) remain a challenging issue since PEEK is bio-inert. In or...

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Autores principales: Wang, Yihan, Zhang, Shutao, Nie, Bin’en, Qu, Xinhua, Yue, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136111/
https://www.ncbi.nlm.nih.gov/pubmed/35646862
http://dx.doi.org/10.3389/fbioe.2022.895288
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author Wang, Yihan
Zhang, Shutao
Nie, Bin’en
Qu, Xinhua
Yue, Bing
author_facet Wang, Yihan
Zhang, Shutao
Nie, Bin’en
Qu, Xinhua
Yue, Bing
author_sort Wang, Yihan
collection PubMed
description Due to excellent mechanical properties and similar elastic modulus compared with human cortical bone, polyetheretherketone (PEEK) has become one of the most promising orthopedic implant materials. However, implant-associated infections (IAIs) remain a challenging issue since PEEK is bio-inert. In order to fabricate an antibacterial bio-functional surface, modifications of PEEK had been widely investigated. This review summarizes the modification strategies to biofunctionalize PEEK for antibacterial. We will begin with reviewing different approaches, such as surface-coating modifications and controlled release of antimicrobials. Furthermore, blending modifications and 3D printing technology were discussed. Finally, we compare the effects among different approaches. We aimed to provide an in-depth understanding of the antibacterial modification and optimize the design of the PEEK orthopedic implant.
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spelling pubmed-91361112022-05-28 Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review Wang, Yihan Zhang, Shutao Nie, Bin’en Qu, Xinhua Yue, Bing Front Bioeng Biotechnol Bioengineering and Biotechnology Due to excellent mechanical properties and similar elastic modulus compared with human cortical bone, polyetheretherketone (PEEK) has become one of the most promising orthopedic implant materials. However, implant-associated infections (IAIs) remain a challenging issue since PEEK is bio-inert. In order to fabricate an antibacterial bio-functional surface, modifications of PEEK had been widely investigated. This review summarizes the modification strategies to biofunctionalize PEEK for antibacterial. We will begin with reviewing different approaches, such as surface-coating modifications and controlled release of antimicrobials. Furthermore, blending modifications and 3D printing technology were discussed. Finally, we compare the effects among different approaches. We aimed to provide an in-depth understanding of the antibacterial modification and optimize the design of the PEEK orthopedic implant. Frontiers Media S.A. 2022-05-13 /pmc/articles/PMC9136111/ /pubmed/35646862 http://dx.doi.org/10.3389/fbioe.2022.895288 Text en Copyright © 2022 Wang, Zhang, Nie, Qu and Yue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wang, Yihan
Zhang, Shutao
Nie, Bin’en
Qu, Xinhua
Yue, Bing
Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review
title Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review
title_full Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review
title_fullStr Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review
title_full_unstemmed Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review
title_short Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review
title_sort approaches to biofunctionalize polyetheretherketone for antibacterial: a review
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136111/
https://www.ncbi.nlm.nih.gov/pubmed/35646862
http://dx.doi.org/10.3389/fbioe.2022.895288
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