Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation

Ecotin is a homodimeric serine protease inhibitor produced by many commensal and pathogenic microbes. It functions as a virulence factor, enabling survival of various pathogens in the blood. The ecotin dimer binds two protease molecules, and each ecotin protomer has two protease-binding sites: site1...

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Detalles Bibliográficos
Autores principales: Nagy, Zoltán Attila, Héja, Dávid, Bencze, Dániel, Kiss, Bence, Boros, Eszter, Szakács, Dávid, Fodor, Krisztián, Wilmanns, Matthias, Kocsis, Andrea, Dobó, József, Gál, Péter, Harmat, Veronika, Pál, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136129/
https://www.ncbi.nlm.nih.gov/pubmed/35483450
http://dx.doi.org/10.1016/j.jbc.2022.101985

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