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Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways

Inflammation is a protective response of the body to an irritant. When an inflammatory response occurs, immune cells are recruited to the injury, eliminating the irritation. The excessive inflammatory response can cause harm to the organism. Inflammation has been found to contribute to cervical canc...

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Autores principales: Zhou, Zi-Wei, Long, Hui-Zhi, Xu, Shuo-Guo, Li, Feng-Jiao, Cheng, Yan, Luo, Hong-Yu, Gao, Li-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136176/
https://www.ncbi.nlm.nih.gov/pubmed/35645817
http://dx.doi.org/10.3389/fphar.2022.899208
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author Zhou, Zi-Wei
Long, Hui-Zhi
Xu, Shuo-Guo
Li, Feng-Jiao
Cheng, Yan
Luo, Hong-Yu
Gao, Li-Chen
author_facet Zhou, Zi-Wei
Long, Hui-Zhi
Xu, Shuo-Guo
Li, Feng-Jiao
Cheng, Yan
Luo, Hong-Yu
Gao, Li-Chen
author_sort Zhou, Zi-Wei
collection PubMed
description Inflammation is a protective response of the body to an irritant. When an inflammatory response occurs, immune cells are recruited to the injury, eliminating the irritation. The excessive inflammatory response can cause harm to the organism. Inflammation has been found to contribute to cervical cancer if there is a problem with the regulation of inflammatory response. Cervical cancer is one of the most common malignant tumors globally, and the incidence tends to be younger. The harm of cervical cancer cannot be ignored. The standard treatments for cervical cancer include surgery, radiotherapy and chemotherapy. However, the prognosis for this treatment is poor, so it is urgent to find a safer and more effective treatment. Natural products are considered excellent candidates for the treatment of cervical cancer. In this review, we first describe the mechanisms by which inflammation induces cervical cancer. Subsequently, we highlight natural products that can treat cervical cancer through inflammatory pathways. We also introduce natural products for the treatment of cervical cancer in clinical trials. Finally, methods to improve the anticancer properties of natural products were added, and the development status of natural products was discussed.
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spelling pubmed-91361762022-05-28 Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways Zhou, Zi-Wei Long, Hui-Zhi Xu, Shuo-Guo Li, Feng-Jiao Cheng, Yan Luo, Hong-Yu Gao, Li-Chen Front Pharmacol Pharmacology Inflammation is a protective response of the body to an irritant. When an inflammatory response occurs, immune cells are recruited to the injury, eliminating the irritation. The excessive inflammatory response can cause harm to the organism. Inflammation has been found to contribute to cervical cancer if there is a problem with the regulation of inflammatory response. Cervical cancer is one of the most common malignant tumors globally, and the incidence tends to be younger. The harm of cervical cancer cannot be ignored. The standard treatments for cervical cancer include surgery, radiotherapy and chemotherapy. However, the prognosis for this treatment is poor, so it is urgent to find a safer and more effective treatment. Natural products are considered excellent candidates for the treatment of cervical cancer. In this review, we first describe the mechanisms by which inflammation induces cervical cancer. Subsequently, we highlight natural products that can treat cervical cancer through inflammatory pathways. We also introduce natural products for the treatment of cervical cancer in clinical trials. Finally, methods to improve the anticancer properties of natural products were added, and the development status of natural products was discussed. Frontiers Media S.A. 2022-05-13 /pmc/articles/PMC9136176/ /pubmed/35645817 http://dx.doi.org/10.3389/fphar.2022.899208 Text en Copyright © 2022 Zhou, Long, Xu, Li, Cheng, Luo and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhou, Zi-Wei
Long, Hui-Zhi
Xu, Shuo-Guo
Li, Feng-Jiao
Cheng, Yan
Luo, Hong-Yu
Gao, Li-Chen
Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways
title Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways
title_full Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways
title_fullStr Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways
title_full_unstemmed Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways
title_short Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways
title_sort therapeutic effects of natural products on cervical cancer: based on inflammatory pathways
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136176/
https://www.ncbi.nlm.nih.gov/pubmed/35645817
http://dx.doi.org/10.3389/fphar.2022.899208
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