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Racial Disparities in Survival of Breast Cancer Patients After Surgery
INTRODUCTION: The racial disparities of opportunity to receive the appropriate intervention and lower insurance coverage may result in survival disparities in different races. This study aims to provide a perspective on racial disparities in the survival of breast cancer patients after surgery. METH...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136217/ https://www.ncbi.nlm.nih.gov/pubmed/35646795 http://dx.doi.org/10.3389/fpubh.2022.831906 |
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author | Wang, Shuhan Tang, Weifang Wang, Shengying Hong, Shikai Liu, Jianjun |
author_facet | Wang, Shuhan Tang, Weifang Wang, Shengying Hong, Shikai Liu, Jianjun |
author_sort | Wang, Shuhan |
collection | PubMed |
description | INTRODUCTION: The racial disparities of opportunity to receive the appropriate intervention and lower insurance coverage may result in survival disparities in different races. This study aims to provide a perspective on racial disparities in the survival of breast cancer patients after surgery. METHODS: Through data from the Surveillance, Epidemiology, and End Results (SEER) program, this study estimated the survival of breast cancer patients of different races from 1998 to 2017. Inverse probability weighting (IPW) was utilized to adjust the imbalanced clinicopathological features of patients of different races. RESULTS: This study analyzed 214,965 breast cancer patients after surgery. Among them, 130,746 patients received BCS, and the remaining 84,219 breast cancer patients underwent mastectomy. Although Asian or Pacific Islander (API) patients after surgery showed higher survival benefit than that of white patients in the primary data, after adjusting for age at diagnosis, luminal subtype, grade, T stage, and N stage in different races, white individuals had the longest period of survival was higher than that of the minority groups in BCS group [breast cancer-specific survival (BCSS): HR(Whitevs.API) = 0.402, HR(Whitevs.Black) = 0.132; P < 0.001; overall survival (OS): HR(Whitevs.API) = 0.689, HR(Whitevs.Black) = 0.254; all P < 0.001] and mastectomy group (BCSS: HR(Whitevs.API) = 0.325, HR(Whitevs.Black) = 0.128; P < 0.001; OS: HR(Whitevs.API) = 0.481, HR(Whitevs.Black) = 0.206; all P < 0.001) CONCLUSIONS: We first identified that the survival benefit of the minority group after surgery was lower than that of white individuals, regardless of tumor chrematistics and surgery types. |
format | Online Article Text |
id | pubmed-9136217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91362172022-05-28 Racial Disparities in Survival of Breast Cancer Patients After Surgery Wang, Shuhan Tang, Weifang Wang, Shengying Hong, Shikai Liu, Jianjun Front Public Health Public Health INTRODUCTION: The racial disparities of opportunity to receive the appropriate intervention and lower insurance coverage may result in survival disparities in different races. This study aims to provide a perspective on racial disparities in the survival of breast cancer patients after surgery. METHODS: Through data from the Surveillance, Epidemiology, and End Results (SEER) program, this study estimated the survival of breast cancer patients of different races from 1998 to 2017. Inverse probability weighting (IPW) was utilized to adjust the imbalanced clinicopathological features of patients of different races. RESULTS: This study analyzed 214,965 breast cancer patients after surgery. Among them, 130,746 patients received BCS, and the remaining 84,219 breast cancer patients underwent mastectomy. Although Asian or Pacific Islander (API) patients after surgery showed higher survival benefit than that of white patients in the primary data, after adjusting for age at diagnosis, luminal subtype, grade, T stage, and N stage in different races, white individuals had the longest period of survival was higher than that of the minority groups in BCS group [breast cancer-specific survival (BCSS): HR(Whitevs.API) = 0.402, HR(Whitevs.Black) = 0.132; P < 0.001; overall survival (OS): HR(Whitevs.API) = 0.689, HR(Whitevs.Black) = 0.254; all P < 0.001] and mastectomy group (BCSS: HR(Whitevs.API) = 0.325, HR(Whitevs.Black) = 0.128; P < 0.001; OS: HR(Whitevs.API) = 0.481, HR(Whitevs.Black) = 0.206; all P < 0.001) CONCLUSIONS: We first identified that the survival benefit of the minority group after surgery was lower than that of white individuals, regardless of tumor chrematistics and surgery types. Frontiers Media S.A. 2022-05-13 /pmc/articles/PMC9136217/ /pubmed/35646795 http://dx.doi.org/10.3389/fpubh.2022.831906 Text en Copyright © 2022 Wang, Tang, Wang, Hong and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Wang, Shuhan Tang, Weifang Wang, Shengying Hong, Shikai Liu, Jianjun Racial Disparities in Survival of Breast Cancer Patients After Surgery |
title | Racial Disparities in Survival of Breast Cancer Patients After Surgery |
title_full | Racial Disparities in Survival of Breast Cancer Patients After Surgery |
title_fullStr | Racial Disparities in Survival of Breast Cancer Patients After Surgery |
title_full_unstemmed | Racial Disparities in Survival of Breast Cancer Patients After Surgery |
title_short | Racial Disparities in Survival of Breast Cancer Patients After Surgery |
title_sort | racial disparities in survival of breast cancer patients after surgery |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136217/ https://www.ncbi.nlm.nih.gov/pubmed/35646795 http://dx.doi.org/10.3389/fpubh.2022.831906 |
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