U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration

Here, we show that direct recruitment of U1A to target transcripts can increase gene expression. This is a new regulatory role, in addition to previous knowledge showing that U1A decreases the levels of U1A mRNA and other specific targets. In fact, genome-wide, U1A more often increases rather than r...

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Detalles Bibliográficos
Autores principales: Rovira, Eric, Moreno, Beatriz, Razquin, Nerea, Hjerpe, Roland, Gonzalez-Lopez, Monika, Barrio, Rosa, Ruiz de los Mozos, Igor, Ule, Jernej, Pastor, Fernando, Blazquez, Lorea, Fortes, Puri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136276/
https://www.ncbi.nlm.nih.gov/pubmed/35664701
http://dx.doi.org/10.1016/j.omtn.2022.05.023

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