Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes?

It is controversial whether the cardiac type-2 ryanodine receptor harboring a catecholaminergic polymorphic ventricular tachycardia-associated point mutation is regulated by luminal or cytosolic Ca(2+). This commentary discusses new findings supporting the cytosolic Ca(2+)-dependent regulation.

Detalles Bibliográficos
Autor principal: Yamaguchi, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136487/
https://www.ncbi.nlm.nih.gov/pubmed/35612555
http://dx.doi.org/10.1085/jgp.202213078
Descripción
Sumario:It is controversial whether the cardiac type-2 ryanodine receptor harboring a catecholaminergic polymorphic ventricular tachycardia-associated point mutation is regulated by luminal or cytosolic Ca(2+). This commentary discusses new findings supporting the cytosolic Ca(2+)-dependent regulation.

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