Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes?

It is controversial whether the cardiac type-2 ryanodine receptor harboring a catecholaminergic polymorphic ventricular tachycardia-associated point mutation is regulated by luminal or cytosolic Ca(2+). This commentary discusses new findings supporting the cytosolic Ca(2+)-dependent regulation.

Detalles Bibliográficos
Autor principal: Yamaguchi, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136487/
https://www.ncbi.nlm.nih.gov/pubmed/35612555
http://dx.doi.org/10.1085/jgp.202213078
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author Yamaguchi, Naohiro
author_facet Yamaguchi, Naohiro
author_sort Yamaguchi, Naohiro
collection PubMed
description It is controversial whether the cardiac type-2 ryanodine receptor harboring a catecholaminergic polymorphic ventricular tachycardia-associated point mutation is regulated by luminal or cytosolic Ca(2+). This commentary discusses new findings supporting the cytosolic Ca(2+)-dependent regulation.
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spelling pubmed-91364872023-03-05 Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes? Yamaguchi, Naohiro J Gen Physiol Commentary It is controversial whether the cardiac type-2 ryanodine receptor harboring a catecholaminergic polymorphic ventricular tachycardia-associated point mutation is regulated by luminal or cytosolic Ca(2+). This commentary discusses new findings supporting the cytosolic Ca(2+)-dependent regulation. Rockefeller University Press 2022-05-25 /pmc/articles/PMC9136487/ /pubmed/35612555 http://dx.doi.org/10.1085/jgp.202213078 Text en © 2022 Yamaguchi https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Yamaguchi, Naohiro
Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes?
title Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes?
title_full Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes?
title_fullStr Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes?
title_full_unstemmed Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes?
title_short Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes?
title_sort do cpvt-linked mutations alter ryr2 regulation by cytosolic ca(2+) in cardiomyocytes?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136487/
https://www.ncbi.nlm.nih.gov/pubmed/35612555
http://dx.doi.org/10.1085/jgp.202213078
work_keys_str_mv AT yamaguchinaohiro docpvtlinkedmutationsalterryr2regulationbycytosolicca2incardiomyocytes

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