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Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca(2+) in cardiomyocytes?
It is controversial whether the cardiac type-2 ryanodine receptor harboring a catecholaminergic polymorphic ventricular tachycardia-associated point mutation is regulated by luminal or cytosolic Ca(2+). This commentary discusses new findings supporting the cytosolic Ca(2+)-dependent regulation.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136487/ https://www.ncbi.nlm.nih.gov/pubmed/35612555 http://dx.doi.org/10.1085/jgp.202213078 |