The role of Trithorax family regulating osteogenic and Chondrogenic differentiation in mesenchymal stem cells

Mesenchymal stem/stromal cells (MSCs) hold great promise and clinical efficacy in bone/cartilage regeneration. With a deeper understanding of stem cell biology over the past decade, epigenetics stands out as one of the most promising ways to control MSCs differentiation. Trithorax group (TrxG) prote...

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Autores principales: Ma, Qingge, Song, Chenghao, Yin, Bei, Shi, Yu, Ye, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136489/
https://www.ncbi.nlm.nih.gov/pubmed/35481717
http://dx.doi.org/10.1111/cpr.13233
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author Ma, Qingge
Song, Chenghao
Yin, Bei
Shi, Yu
Ye, Ling
author_facet Ma, Qingge
Song, Chenghao
Yin, Bei
Shi, Yu
Ye, Ling
author_sort Ma, Qingge
collection PubMed
description Mesenchymal stem/stromal cells (MSCs) hold great promise and clinical efficacy in bone/cartilage regeneration. With a deeper understanding of stem cell biology over the past decade, epigenetics stands out as one of the most promising ways to control MSCs differentiation. Trithorax group (TrxG) proteins, including the COMPASS family, ASH1L, CBP/p300 as histone modifying factors, and the SWI/SNF complexes as chromatin remodelers, play an important role in gene expression regulation during the process of stem cell differentiation. This review summarises the components and functions of TrxG complexes. We provide an overview of the regulation mechanisms of TrxG in MSCs osteogenic and chondrogenic differentiation, and discuss the prospects of epigenetic regulation mediated by TrxG in bone and cartilage regeneration.
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spelling pubmed-91364892022-06-04 The role of Trithorax family regulating osteogenic and Chondrogenic differentiation in mesenchymal stem cells Ma, Qingge Song, Chenghao Yin, Bei Shi, Yu Ye, Ling Cell Prolif Reviews Mesenchymal stem/stromal cells (MSCs) hold great promise and clinical efficacy in bone/cartilage regeneration. With a deeper understanding of stem cell biology over the past decade, epigenetics stands out as one of the most promising ways to control MSCs differentiation. Trithorax group (TrxG) proteins, including the COMPASS family, ASH1L, CBP/p300 as histone modifying factors, and the SWI/SNF complexes as chromatin remodelers, play an important role in gene expression regulation during the process of stem cell differentiation. This review summarises the components and functions of TrxG complexes. We provide an overview of the regulation mechanisms of TrxG in MSCs osteogenic and chondrogenic differentiation, and discuss the prospects of epigenetic regulation mediated by TrxG in bone and cartilage regeneration. John Wiley and Sons Inc. 2022-04-28 /pmc/articles/PMC9136489/ /pubmed/35481717 http://dx.doi.org/10.1111/cpr.13233 Text en © 2022 The Authors. Cell Proliferation published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Ma, Qingge
Song, Chenghao
Yin, Bei
Shi, Yu
Ye, Ling
The role of Trithorax family regulating osteogenic and Chondrogenic differentiation in mesenchymal stem cells
title The role of Trithorax family regulating osteogenic and Chondrogenic differentiation in mesenchymal stem cells
title_full The role of Trithorax family regulating osteogenic and Chondrogenic differentiation in mesenchymal stem cells
title_fullStr The role of Trithorax family regulating osteogenic and Chondrogenic differentiation in mesenchymal stem cells
title_full_unstemmed The role of Trithorax family regulating osteogenic and Chondrogenic differentiation in mesenchymal stem cells
title_short The role of Trithorax family regulating osteogenic and Chondrogenic differentiation in mesenchymal stem cells
title_sort role of trithorax family regulating osteogenic and chondrogenic differentiation in mesenchymal stem cells
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136489/
https://www.ncbi.nlm.nih.gov/pubmed/35481717
http://dx.doi.org/10.1111/cpr.13233
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