PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α–GLUT2 pathway

Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia by activating the pregnane X receptor (PXR), but the mechanism is unclear. Here, we report that PXR activation induces hyperglycemia by impairing hepatic glucose metabolism due to inhibition of the hepatocyte nucl...

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Detalles Bibliográficos
Autores principales: Liu, Peihua, Jiang, Ling, Kong, Weimin, Xie, Qiushi, Li, Ping, Liu, Xiaonan, Zhang, Jiayi, Liu, Ming, Wang, Zhongjian, Zhu, Liang, Yang, Hanyu, Zhou, Ying, Zou, Jianjun, Liu, Xiaodong, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136535/
https://www.ncbi.nlm.nih.gov/pubmed/35646519
http://dx.doi.org/10.1016/j.apsb.2021.09.031

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