The lactate-NAD(+) axis activates cancer-associated fibroblasts by downregulating p62

Reduced p62 levels are associated with the induction of the cancer-associated fibroblast (CAF) phenotype, which promotes tumorigenesis in vitro and in vivo through inflammation and metabolic reprogramming. However, how p62 is downregulated in the stroma fibroblasts by tumor cells to drive CAF activa...

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Detalles Bibliográficos
Autores principales: Linares, Juan F., Cid-Diaz, Tania, Duran, Angeles, Osrodek, Marta, Martinez-Ordoñez, Anxo, Reina-Campos, Miguel, Kuo, Hui-Hsuan, Elemento, Olivier, Martin, M. Laura, Cordes, Thekla, Thompson, Timothy C., Metallo, Christian M., Moscat, Jorge, Diaz-Meco, Maria T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136538/
https://www.ncbi.nlm.nih.gov/pubmed/35545049
http://dx.doi.org/10.1016/j.celrep.2022.110792

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