Detailed resume of RNA m(6)A demethylases

N6-Methyladenosine (m(6)A) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, m(6)A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Dandan, Wang, Bo, Gao, Ya, Zhao, Lijuan, Bi, Yaping, Zhang, Jinge, Wang, Ning, Kang, Huiqin, Pang, Jingru, Liu, Ying, Pang, Luping, Chen, Zhe-Sheng, Zheng, Yi-Chao, Liu, Hong-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136571/
https://www.ncbi.nlm.nih.gov/pubmed/35646549
http://dx.doi.org/10.1016/j.apsb.2022.01.003
Descripción
Sumario:N6-Methyladenosine (m(6)A) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, m(6)A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m(6)A demethylases have been reported, fat mass and obesity-associated protein (FTO) and alkylation protein AlkB homolog 5 (ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5.

Ejemplares similares