Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1

Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron- and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple he...

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Detalles Bibliográficos
Autores principales: Luo, Piao, Liu, Dandan, Zhang, Qian, Yang, Fan, Wong, Yin-Kwan, Xia, Fei, Zhang, Junzhe, Chen, Jiayun, Tian, Ya, Yang, Chuanbin, Dai, Lingyun, Shen, Han-Ming, Wang, Jigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136576/
https://www.ncbi.nlm.nih.gov/pubmed/35646542
http://dx.doi.org/10.1016/j.apsb.2021.12.007

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