Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood

Aristolochic acids (AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I (AAI) reacts with DNA to form covalent aristolactam (AL)–DNA adducts, leading to subsequent A to T transversion mutation, commonly referred as AA mutational signature. Previous re...

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Detalles Bibliográficos
Autores principales: Chen, Shuzhen, Dong, Yaping, Qi, Xinming, Cao, Qiqi, Luo, Tao, Bai, Zhaofang, He, Huisi, Fan, Zhecai, Xu, Lingyan, Xing, Guozhen, Wang, Chunyu, Jin, Zhichao, Li, Zhixuan, Chen, Lei, Zhong, Yishan, Wang, Jiao, Ge, Jia, Xiao, Xiaohe, Bian, Xiuwu, Wen, Wen, Ren, Jin, Wang, Hongyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136577/
https://www.ncbi.nlm.nih.gov/pubmed/35646530
http://dx.doi.org/10.1016/j.apsb.2021.11.011

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