Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety

Drug optimization, which improves drug potency/specificity by structure‒activity relationship (SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However, the current drug optimization may overlook the structure‒tissue exposure/selectivity-relations...

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Detalles Bibliográficos
Autores principales: Gao, Wei, Hu, Hongxiang, Dai, Lipeng, He, Miao, Yuan, Hebao, Zhang, Huixia, Liao, Jinhui, Wen, Bo, Li, Yan, Palmisano, Maria, Traore, Mohamed Dit Mady, Zhou, Simon, Sun, Duxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136610/
https://www.ncbi.nlm.nih.gov/pubmed/35646532
http://dx.doi.org/10.1016/j.apsb.2022.02.015

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