Drug discovery of sclerostin inhibitors

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic...

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Detalles Bibliográficos
Autores principales: Yu, Sifan, Li, Dijie, Zhang, Ning, Ni, Shuaijian, Sun, Meiheng, Wang, Luyao, Xiao, Huan, Liu, Dingdong, Liu, Jin, Yu, Yuanyuan, Zhang, Zongkang, Yeung, Samuel Tin Yui, Zhang, Shu, Lu, Aiping, Zhang, Zhenlin, Zhang, Baoting, Zhang, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136615/
https://www.ncbi.nlm.nih.gov/pubmed/35646527
http://dx.doi.org/10.1016/j.apsb.2022.01.012

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